Strahlentherapie und Onkologie

, Volume 175, Supplement 2, pp 57–63

Proton therapy for tumors of the skull base

  • John E. Munzenrider
  • Norbert J. Liebsch
Clinical Aspects of Hadron Therapy

DOI: 10.1007/BF03038890

Cite this article as:
Munzenrider, J.E. & Liebsch, N.J. Strahlenther Onkol (1999) 175(Suppl 2): 57. doi:10.1007/BF03038890


Charged particle beams are ideal for treating skull base and cervical spine tumors: dose can be focused in the target, while achieving significant sparing of the brain, brain stem, cervical cord, and optic nerves and chiasm. For skull base tumors, 10-year local control rates with combined proton-photon therapy are highest for chondrosarcomas, intermediate for male chordomas, and lowest for female chordomas (94%, 65%, and 42%, respectively). For cervical spine tumors, 10-year local control rates are not significantly different for chordomas and chondrosarcomas (54% and 48%, respectively), nor is there any difference in local control between males and females. Observed treatment-related morbidity has been judged acceptable, in view of the major morbidity and mortality which accompany uncontrolled tumor growth.

Key Words

Proton therapySkull baseChordomaChondrosarcoma3D conformal radiation therapy

Copyright information

© Urban & Vogel 1999

Authors and Affiliations

  • John E. Munzenrider
    • 1
  • Norbert J. Liebsch
    • 1
  1. 1.Department of Radiation Oncology, Massachusett General HospitalHarvard University Medical SchoolBostonUSA