Circulating testosterone and prostate cancer. A brief review
- Pär StattinAffiliated withDept of Urology and Andrology, Umeå University Hospital Email author
In vitro andin vivo studies show that androgens stimulate prostate cancer. However, evidence from epidemiological studies of an association between circulating levels of androgens and prostate cancer risk has been inconsistent, but most studies have likely been undersized given that the association may be relatively weak.
We review prospective studies on the association of serum levels of free and total testosterone, the principal androgen in circulation with risk of prostate cancer.
No significant association between total or free testosterone and risk of prostate cancer was found in studies that together included 1,525 cases of prostate cancer and 4,349 controls.
No support was found for the hypothesis that high levels of circulating testosterone within a physiological range stimulate development and growth of prostate cancer. Intraprostatic androgen metabolism may still be of importance for prostate cancer development.
Key wordsprostate cancer androgens testosterone epidemiology prospective studies
- Circulating testosterone and prostate cancer. A brief review
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Volume 14, Issue 4 , pp 375-380
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- prostate cancer
- prospective studies
- Pär Stattin (1)
- Author Affiliations
- 1. Dept of Urology and Andrology, Umeå University Hospital, 901 85, Umeå, Sweden