Neurotoxicity Research

, Volume 2, Issue 2, pp 229–237

Prospects for redox-based therapy in neurodegenerative diseases

Article

DOI: 10.1007/BF03033796

Cite this article as:
Friedlich, A.L. & Beal, M.F. neurotox res (2000) 2: 229. doi:10.1007/BF03033796

Abstract

Accumulating evidence supports a primary role for perturbations in redox metabolism in the pathogenesis of many neurodegenerative diseases. This evidence derives mainly from molecular genetic analysis, direct observation from post-mortem human brain, and biochemical, pathologic, and therapeutic studies in transgenic and other animal models of neurodegeneration. We review here the evidence for redox-mediated pathogenesis in neurodegenerative diseases. The emerging class of redox-based therapeutic agents is then discussed. Drugs of this class are distinguished by their proximate effect, which is oxidative and not phosphorylative.

Keywords

Alzheimer’s disease Amyotrophic lateral sclerosis Huntington’s disease Oxidative damage Neurodegeneration Parkinson’s disease Redox-based therapy Transgenic mouse models 

Copyright information

© Springer 2000

Authors and Affiliations

  1. 1.Department of Neurology and NeuroscienceWeill Medical College of Cornell UniversityNew YorkUSA

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