Pathology Oncology Research

, Volume 8, Issue 2, pp 125-128

First online:

Down regulation of endothelial adhesion molecules in node positive breast cancer: Possible failure of host defence mechanism

  • Maya MadhavanAffiliated withResearch Division, Regional Cancer Centre
  • , Priya Srinivas
  • , Elizabeth AbrahamAffiliated withDivision of Histopathology, Regional Cancer Centre
  • , Iqbal AhmedAffiliated withDivision of Surgical Oncology, Regional Cancer Centre
  • , N. R. VijayalekshmiAffiliated withDepartment of Biochemistry, University of Kerala
  • , Prabha BalaramAffiliated withResearch Division, Regional Cancer Centre Email author 

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Endothelial cell adhesion molecules (CAMs) are important in tumorigenesis and host defense mechanism. Their status in breast cancer with regard to nodal invasion is not yet known. Hence we looked at the expression of three important CAMs: VCAM, ICAM and E-selectin. A downregulation of all these CAMs was noted in node positive breast cancer in comparison to node negative cases. This suggests shedding of these molecules in cases with nodal metastasis which might help the tumor cells to escape the host defense mechanism. On multivariate analysis, VCAM alone emerged as an independent predictor of nodal metastasis.


VCAM ICAM E-selectin invasion breast cancer