Pathology Oncology Research

, Volume 8, Issue 2, pp 125–128

Down regulation of endothelial adhesion molecules in node positive breast cancer: Possible failure of host defence mechanism

  • Maya Madhavan
  • Priya Srinivas
  • Elizabeth Abraham
  • Iqbal Ahmed
  • N. R. Vijayalekshmi
  • Prabha Balaram
Article

DOI: 10.1007/BF03033721

Cite this article as:
Madhavan, M., Srinivas, P., Abraham, E. et al. Pathol. Oncol. Res. (2002) 8: 125. doi:10.1007/BF03033721

Abstract

Endothelial cell adhesion molecules (CAMs) are important in tumorigenesis and host defense mechanism. Their status in breast cancer with regard to nodal invasion is not yet known. Hence we looked at the expression of three important CAMs: VCAM, ICAM and E-selectin. A downregulation of all these CAMs was noted in node positive breast cancer in comparison to node negative cases. This suggests shedding of these molecules in cases with nodal metastasis which might help the tumor cells to escape the host defense mechanism. On multivariate analysis, VCAM alone emerged as an independent predictor of nodal metastasis.

Keywords

VCAMICAME-selectininvasionbreast cancer

Copyright information

© Arányi Lajos Foundation 2002

Authors and Affiliations

  • Maya Madhavan
    • 1
  • Priya Srinivas
  • Elizabeth Abraham
    • 2
  • Iqbal Ahmed
    • 3
  • N. R. Vijayalekshmi
    • 4
  • Prabha Balaram
    • 1
  1. 1.Research DivisionRegional Cancer CentreTrivandrum, KeralaIndia
  2. 2.Division of HistopathologyRegional Cancer CentreTrivandrum, Kerala
  3. 3.Division of Surgical OncologyRegional Cancer CentreTrivandrum, Kerala
  4. 4.Department of BiochemistryUniversity of KeralaTrivandrum, KeralaIndia