Article

Neurotoxicity Research

, Volume 6, Issue 4, pp 327-332

Studies on homocysteine and dehydroepiandrosterone sulphate plasma levels in alzheimer’s disease patients and in Parkinson’s disease patients

  • S. GenedaniAffiliated withDepartment of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia
  • , G. RasioAffiliated withLaboratory of Clinical Chemistry, Ospedale “Nuovo Montecchi”
  • , P. CortelliAffiliated withInstitute of Clinical Neurology, University of Modena and Reggio Emilia
  • , F. AntonelliAffiliated withInstitute of Clinical Neurology, University of Modena and Reggio Emilia
  • , D. GuidolinAffiliated withDepartment of Human Anatomy and Physiology, Section of Human Anatomy, University of Padova
  • , M. GalantucciAffiliated withDepartment of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia
  • , K. FuxeAffiliated withDepartment of Neuroscience, Karolinska Insitutet
  • , L. F. AgnatiAffiliated withDepartment of Biomedical Sciences, Section of Physiology, University of Modena and Reggio Emilia Email author 

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Abstract

Homocysteine (HC) and dehydroepiandrosterone sulphate (DHEAS) plasma levels have been evaluated in groups of male and female patients with Parkinson’s Disease (PD) and in a group of female patients with Alzheimer’s Disease (AD) and compared with the corresponding plasma levels observed in a group of age-matched subjects. It has been confirmed that HC plasma levels are enhanced in both PD and AD patients.

As far as the DHEAS plasma levels are concerned no changes have been observed in PD patients while a marked decrease has been observed in AD patients. These results support the view that while the pro-oxidant effects of HC and its agonist action at NMDA receptors can play a role in both neu-rodegenerative diseases, the role of DHEAS is more complex and may be an important factor only in certain neurodegenerative diseases. Thus, according to the present study DHEAS is likely to be involved in AD but not in PD.

Keywords

Homocysteine Alzheimer’s disease Parkinson’s disease Dehydroepiandrosterone sulphate Human patients