Neurotoxicity Research

, Volume 9, Issue 1, pp 29–37

Curcumin induces stress response, neurite outgrowth and prevent nf-κb activation by inhibiting the proteasome function

  • Priyanka Dikshit
  • Anand Goswami
  • Amit Mishra
  • Mou Catterjee
  • Nihar Ranjan Jana
Article

DOI: 10.1007/BF03033305

Cite this article as:
Dikshit, P., Goswami, A., Mishra, A. et al. neurotox res (2006) 9: 29. doi:10.1007/BF03033305

Abstract

Curcumin, a natural polyphenolic compound, has long been known as an anti-tumour and anti-inflammatory compound; although, the common mechanism through which it exhibits such properties are remains unclear. Recently, we reported that the curcumin-induced apoptosis is mediated through the impairment of ubiquitin proteasome system (UPS). Here, we show that curcumin disrupts UPS function by directly inhibiting the enzyme activity of the proteasome’s 20S core catalytic component. Like other proteasome inhibitors, curcumin exposure induces neurite outgrowth and the stress response, as evident from the induction of various cytosolic and endoplasmic reticulum chaperones as well as induction of transcription factor CHOP/GADD153. The direct inhibition of proteasome activity also causes an increase in half-life of IκB-α that ultimately leads to the down-regulation of NF-κB activation. These results suggest that curcumin-induced proteasomal malfunction might be linked with both anti-proliferative and anti-inflammatory activities.

Keywords

CurcuminProteasomeIκBNF-κBStress

Copyright information

© Springer 2006

Authors and Affiliations

  • Priyanka Dikshit
    • 1
  • Anand Goswami
    • 1
  • Amit Mishra
    • 1
  • Mou Catterjee
    • 1
  • Nihar Ranjan Jana
    • 1
  1. 1.Cellular and Molecular Neuroscience LaboratoryNational Brain Research CentreManesar, GurgaonIndia