Neurotoxicity Research

, Volume 9, Issue 1, pp 23–28

Lipid peroxidative damage on malathion exposure in rats

Authors

  • JucÉlia J. Fortunato
    • Laboratório de NeurociênciasUniversidade do Extremo Sul Catarinense
  • Fabiano R. Agostinho
    • Laboratório de Fisiopatologia ExperimentalUniversidade do Extremo Sul Catarinense
  • Gislaine Z. RÉus
    • Laboratório de NeurociênciasUniversidade do Extremo Sul Catarinense
  • FabrÍcia C. Petronilho
    • Laboratório de Fisiopatologia ExperimentalUniversidade do Extremo Sul Catarinense
  • Felipe Dal-Pizzol
    • Laboratório de Fisiopatologia ExperimentalUniversidade do Extremo Sul Catarinense
    • Laboratório de NeurociênciasUniversidade do Extremo Sul Catarinense
Article

DOI: 10.1007/BF03033304

Cite this article as:
Fortunato, J.J., Agostinho, F.R., RÉus, G.Z. et al. neurotox res (2006) 9: 23. doi:10.1007/BF03033304

Abstract

Lipid peroxidation is one of the major outcomes of free radical-mediated injury to tissuein vivo, including the central nervous system (CNS). The aim of this study was to examine whether malathion, a commonly used organophosphorus (OP), might induce oxidative stress in cerebrospinal fluid, blood serum and brain structures in male Wistar rats. Malathion was administered intraperitoneally in the doses of 25, 50, 100 and 150 mg/kg for 28 days. Oxidative damage was determined by measuring the thiobarbituric acid reactive species (TBARS) content, as an index of lipid peroxidation. TBARS concentration in the cerebrospinal fluid (CSF) and brain structures were increased, but a decrease in TBARS concentration in serum was observed. The results of the present study suggest the usefulness of TBARS measurement as a good biomarker in the estimation of malathion-induced oxidative stress affecting CSF and brain structures.

Keywords

MalathionLipid peroxidationOxidative stressBrain structuresCerebrospinal fluidBlood serum

Copyright information

© Springer 2006