Lipid peroxidative damage on malathion exposure in rats
Received: 26 January 2005 Revised: 13 July 2005 DOI:
Cite this article as: Fortunato, J.J., Agostinho, F.R., RÉus, G.Z. et al. neurotox res (2006) 9: 23. doi:10.1007/BF03033304 Abstract
Lipid peroxidation is one of the major outcomes of free radical-mediated injury to tissue
in vivo, including the central nervous system (CNS). The aim of this study was to examine whether malathion, a commonly used organophosphorus (OP), might induce oxidative stress in cerebrospinal fluid, blood serum and brain structures in male Wistar rats. Malathion was administered intraperitoneally in the doses of 25, 50, 100 and 150 mg/kg for 28 days. Oxidative damage was determined by measuring the thiobarbituric acid reactive species (TBARS) content, as an index of lipid peroxidation. TBARS concentration in the cerebrospinal fluid (CSF) and brain structures were increased, but a decrease in TBARS concentration in serum was observed. The results of the present study suggest the usefulness of TBARS measurement as a good biomarker in the estimation of malathion-induced oxidative stress affecting CSF and brain structures. Keywords Malathion Lipid peroxidation Oxidative stress Brain structures Cerebrospinal fluid Blood serum References
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