Neurotoxicity Research

, Volume 3, Issue 3, pp 277–280

Methamphetamine causes depletion of glutathione and an increase in oxidized glutathione in the rat striatum and prefrontal cortex

  • Osman Açikgöz
  • Sevil Gönenç
  • Semra Gezer
  • Berkant Muammer Kayatekin
  • Nazan Uysal
  • Ilgi şemin
  • Ataman Güre
Article

DOI: 10.1007/BF03033266

Cite this article as:
Açikgöz, O., Gönenç, S., Gezer, S. et al. neurotox res (2001) 3: 277. doi:10.1007/BF03033266

Abstract

The administration of methamphetamine to experimental animals results in damage to dopaminergic neurons. The hypothesis that methampheta-mine-induced neurotoxicity is mediated by reactive oxygen species was evaluated. It was found that acute administration of methamphetamine (5 and 15 mg kg-1) resulted in production of oxidative stress as demonstrated by decreased glutathione and increased oxidized glutathione levels in the rat striatum and prefrontal cortex. These changes in glutathione and oxidized glutathione levels were dose-dependent in striatum, but not in prefrontal cortex. In conclusion, the results of present study provide further evidence in support of the notion that oxidative stress may play an important role in the metham-phetamine-induced neurotoxicity.

Keywords

Glutathione Methamphetamine Oxidative stress Prefrontal cortex Striatum 

Copyright information

© Springer 2001

Authors and Affiliations

  • Osman Açikgöz
    • 1
  • Sevil Gönenç
    • 1
  • Semra Gezer
    • 2
  • Berkant Muammer Kayatekin
    • 1
  • Nazan Uysal
    • 1
  • Ilgi şemin
    • 1
  • Ataman Güre
    • 1
  1. 1.Department of PhysiologyDokuz Eylül University Medical SchoolBalçovaTurkey
  2. 2.Department of BiochemistryDokuz Eylül University Medical SchoolBalçovaTurkey

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