Pathology Oncology Research

, Volume 7, Issue 1, pp 6–13

Molecular genetic abnormalities in the pathogenesis of human lung cancer

  • Eva Forgacs
  • Sabine Zöchbauer-Müller
  • Edit Oláh
  • John D. Minna
Review

DOI: 10.1007/BF03032598

Cite this article as:
Forgacs, E., Zöchbauer-Müller, S., Oláh, E. et al. Pathol. Oncol. Res. (2001) 7: 6. doi:10.1007/BF03032598
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Abstract

In the past few years our knowledge of the molecular pathogenesis of lung cancer has significantly increased. There are several molecular mechanisms involved in the multistage carcinogenesis through which respiratory epithelial cells become preneoplastic and then invasive cancer. In this review we summarize some of these changes including, genomic alterations such as loss of heterozygosity and microsatellite alterations, autocrine-paracrine loops, alterations in oncogenes and tumor suppressor genes, tumor angiogenesis, aberrant promoter methylation and inherited predisposition to lung cancer. Translation of these findings to the clinic is also discussed.

Keywords

oncogene tumor suppressor gene autocrine signal transduction cell cycle mutation methylation telomerase kangiogenesis preneoplasia 

Copyright information

© Arányi Lajos Foundation 2001

Authors and Affiliations

  • Eva Forgacs
    • 1
  • Sabine Zöchbauer-Müller
    • 1
  • Edit Oláh
    • 2
  • John D. Minna
    • 1
  1. 1.Hamon Center for Therapeutic Oncology ResearchUniversity of Texas Southwestern Medical Center at DallasDallas
  2. 2.Department of Molecular BiologyNational Institute of OncologyBudapestHungary

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