Annals of Nuclear Medicine

, Volume 17, Issue 6, pp 511–515

Imaging of adenosine A1 receptors in the human brain by positron emission tomography with [11C]MPDX

  • Nobuyoshi Fukumitsu
  • Kenji Ishii
  • Yuichi Kimura
  • Keiichi Oda
  • Toru Sasaki
  • Yutaka Mori
  • Kiichi Ishiwata
Short Communication

DOI: 10.1007/BF03006445

Cite this article as:
Fukumitsu, N., Ishii, K., Kimura, Y. et al. Ann Nucl Med (2003) 17: 511. doi:10.1007/BF03006445

Abstract

We report the first clinical PET study using [1-methyl-11C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine ([11C]MPDX) for imaging adenosine A1 receptors in the human brain. The binding of [11C]MPDX evaluated quantitatively as the distribution volume by a graphical analysis was high in the striatum and thalamus, and low in the cerebellum. The distribution pattern of [11C]MPDX was coincident with that of adenosine A1 receptorsin vitro reported previously, and was different from those of blood flow and [18F]FDG. The [11C]MPDX PET has the potential for mapping adenosine A1 receptors in the human brain.

Key words

[11C]MPDXadenosine A1 receptorpositron emission tomography

Copyright information

© Springer 2003

Authors and Affiliations

  • Nobuyoshi Fukumitsu
    • 1
    • 2
  • Kenji Ishii
    • 1
  • Yuichi Kimura
    • 1
  • Keiichi Oda
    • 1
  • Toru Sasaki
    • 1
  • Yutaka Mori
    • 2
  • Kiichi Ishiwata
    • 1
  1. 1.Positron Medical CenterTokyo Metropolitan Institute of GerontologyTokyoJapan
  2. 2.Department of RadiologyJikei University School of MedicineTokyoJapan