Annals of Nuclear Medicine

, Volume 14, Issue 1, pp 69–74

Preliminary evaluation of [1-11C]octanoate as a PET tracer for studying cerebral ischemia: A PET study in rat and canine models of focal cerebral ischemia

Authors

    • Institute for Biofunetional Research Co., Ltd.
    • Department of Tracer KineticsHokkaido University School of Medicine
  • Hidefumi Kawashima
    • Institute for Biofunetional Research Co., Ltd.
  • Tadatoshi Hashimoto
    • Takeda Chemical Industries Co., Ltd.
  • Mitsuaki Imanishi
    • Takeda Chemical Industries Co., Ltd.
  • Mie Shiomi
    • Takeda Chemical Industries Co., Ltd.
  • Kazuo Minematsu
    • Cerebrovascular Division, Department of MedicineNational Cardiovascular Center
  • Yasuhiro Hasegawa
    • Cerebrovascular Division, Department of MedicineNational Cardiovascular Center
  • Takenori Yamaguchi
    • Cerebrovascular Division, Department of MedicineNational Cardiovascular Center
  • Yoshihiro Miyake
    • Institute for Biofunetional Research Co., Ltd.
  • Naoto Hashimoto
    • Institute for Biofunetional Research Co., Ltd.
Short Communications

DOI: 10.1007/BF02990482

Cite this article as:
Kuge, Y., Kawashima, H., Hashimoto, T. et al. Ann Nucl Med (2000) 14: 69. doi:10.1007/BF02990482

Abstract

Octanoate is taken up into the brain and is converted in astrocytes to glutamine through the TCA cycle after β-oxidation. We speculate that [1-11C]octanoate may be used as a tracer for astroglial functions and/or fatty acid metabolism in the brain and may be useful for studying cerebral ischemia. In the present study we investigated brain distribution of [1-11C]octanoate and compared it with cerebral blood flow (CBF) by using rat and canine models of middle cerebral artery (MCA) occlusion and a high resolution PET. In rats brain distribution of [15O]H2O measured 1–2 h and 5–6 h after insult was compared with that of [1-11C]octanoate measured 3–4 h after insult. Radioactivity ratios of lesioned to normal hemispheres determined with [15O]H2O were lower than those determined with [1-11C]octanoate. These results were confirmed by a study on a canine model of MCA-occlusion. Twenty-four hours after insult, CBF decreased in the MCA-territory of the occluded hemisphere, whereas normal or higher accumulation of [1-11C]octanoate was observed in the ischemic regions. The uptake of [1-11C]octanoate-derived radioactivity therefore increased relative to CBF in the ischemic regions, indicating that [1-11C]octanoate provides functional information different from CBF. In conclusion, we found that [1-11C]octanoate is a potential radiopharmaceutical for studying the pathophysiology of cerebral ischemia.

Key words

[1-11C]octanoatepositron emission tomographycerebral ischemiaratdog

Copyright information

© Springer 2000