Selenium chemoprevention of liver cancer in animals and possible human applications
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An inverse correlation between geographic distribution of liver cancer incidence and the selenium (Se) contents of whole blood and grains was observed in Qidong county, Jiangsu province, a high liver cancer area of the People’s Republic of China. Animal experiments demonstrated that supplementation of Se reduced the incidence of liver cancer in rats exposed to aflatoxin B1. Se was also shown to inhibit the growth of transplanted tumors. A lower incidence of liver preneoplastic alterations and reduction of hepatitis B virus infection in ducks by Se-supplementation was observed, and three pilot studies for a Se-intervention trial on human liver cancer were carried out on the residents of Qidong county. A protective effect on the cellular DNA damage induced by aflatoxin B1 was observed in lympocytes from human with Se-supplements.
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- Selenium chemoprevention of liver cancer in animals and possible human applications
Biological Trace Element Research
Volume 15, Issue 1 , pp 231-241
- Cover Date
- Print ISSN
- Online ISSN
- Humana Press
- Additional Links
- liver cancer incidence correlation
- selenium supplement, rats, ducks, human
- selenium antihepatocarcinogenesis
- hepatitis B virus infection
- selenium, humans, chemoprevention trial, intermediated endpoint, unscheduled DNA synthesis
- Industry Sectors