Biological Trace Element Research

, Volume 15, Issue 1, pp 231–241

Selenium chemoprevention of liver cancer in animals and possible human applications

  • S. Y. Yu
  • Y. J. Chu
  • W. G. Li
Article

DOI: 10.1007/BF02990140

Cite this article as:
Yu, S.Y., Chu, Y.J. & Li, W.G. Biol Trace Elem Res (1988) 15: 231. doi:10.1007/BF02990140

Abstract

An inverse correlation between geographic distribution of liver cancer incidence and the selenium (Se) contents of whole blood and grains was observed in Qidong county, Jiangsu province, a high liver cancer area of the People’s Republic of China. Animal experiments demonstrated that supplementation of Se reduced the incidence of liver cancer in rats exposed to aflatoxin B1. Se was also shown to inhibit the growth of transplanted tumors. A lower incidence of liver preneoplastic alterations and reduction of hepatitis B virus infection in ducks by Se-supplementation was observed, and three pilot studies for a Se-intervention trial on human liver cancer were carried out on the residents of Qidong county. A protective effect on the cellular DNA damage induced by aflatoxin B1 was observed in lympocytes from human with Se-supplements.

Index Entries

Seleniumliver cancer incidence correlationselenium supplement, rats, ducks, humanselenium antihepatocarcinogenesishepatitis B virus infectionselenium, humans, chemoprevention trial, intermediated endpoint, unscheduled DNA synthesis

Copyright information

© Humana Press Inc. 1988

Authors and Affiliations

  • S. Y. Yu
    • 1
  • Y. J. Chu
    • 1
  • W. G. Li
    • 2
  1. 1.Cancer InstituteChinese Academy of Medical SciencesBeijingChina
  2. 2.Qidong Liver Cancer InstituteJiangsuChina