Genetical studies on the skeleton of the mouse
- Hans Grüneberg
- … show all 1 hide
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The genetical behaviour of a number of skeletal characters which differentiate the pure lines CBA and C57BL is described in crosses between these two strains, between C57BL and A, and in some subsidiary experiments.
The results indicate that the entities investigated are ‘quasi-continuous’ characters in the sense that the underlying genetic basis is a continuous variable (generally not yet identified) with multiple factor inheritance which is divided by a physiological threshold into normal and abnormal animals; the abnormality is usually itself capable of graded expression.
The peculiar genetical properties of quasi-continuous characters are regarded as partly due to the fact that a continuous distribution may occupy any position in relation to a physiological threshold; and partly that they share with ordinary continuous variables the multiple gene basis and the sensitivity to influences of the environment, both prenatal and post-natal.
It is suggested that additiveness of gene effects and sensitivity to the environment may trace back to the common cause that the so-called multiple genes of quantitative genetics are in fact remote gene effects. It is pointed out that arbitrarily chosen parameters will generally be influenced by genes only indirectly; and as every measurement involves a choice and is thus arbitrary, the multiple gene inheritance generally encountered in quantitative genetics may be due to the arbitrary choice of parameters rather than to inherent causes.
- Fuller, J. L., Easler, C. &Smith, M. E. (1950). Inheritance of audiogenic seizure susceptibility in the mouse.Genetics,35, 622–32.
- Goldschmidt, R. B., Hannah, A. &Piternick, L. K. (1951). The podoptera effect inDrosophila melanogaster.Univ. Calif. Publ. Zool. 55, 67–294.
- Grüneberg, H. (1950a). Genetical studies on the skeleton of the mouse. I. Minor variations of the vertebral column.J. Genet. 50, 112–41.
- Grüneberg, H. (1950b). Genetical studies on the skeleton of the mouse. II. Undulated and its ‘modifiers’.J. Genet. 50, 142–73.
- Grüneberg, H. (1950c). Skeletal polymorphism in the mouse. InModerne Biologie, Festschrift zum 60. Geburtstag von Hans Nachtsheim (Berlin, F. W. Peters), pp. 43–54.
- Grüneberg, H. (1951). The genetics of a tooth defect in the mouse.Proc. Roy. Soc. B,138, 437–51.
- Grüneberg, H. (1952).The Genetics of the Mouse, 2nd ed., revised and enlarged. Pp. xvii+650. Martinus Nijhoff: The Hague.
- Kühn, A., Caspari, E. &Plagge, E. (1935). Über hormonale Genwirkungen beiEphestia kühniella Z.Nachr. Ges. Wiss. Göttingen, N.F., Nachr. Biol.,2, 1–29.
- Mather, K. &Harrison, B. J. (1949). The manifold effects of selection.Heredity,3, 1–52 and 131–62. CrossRef
- Penrose, L. S. (1951). Measurement of pleiotropic effects in phenylketonuria.Ann. Eugen., Lond.,16, 134–41.
- Russell, W. L. (1948). Maternal influence on number of lumbar vertebrae in mice raised from transplanted ovaries.Genetics,33, 627–8 (Abstr.).
- Spurway, H. (1948). Genetics and cytology ofDrosophila subobscura. IV. An extreme example of delay in gene action, causing sterility.J. Genet. 49, 126–40. CrossRef
- Truslove, G. M. (1952). Genetical studies on the skeleton of the mouse. V. ‘Interfrontal’ and ‘parted frontals’.J. Genet. 51, 115–22.
- Weber, W. (1950). Genetical studies on the skeleton of the mouse. III. Skeletal variations in wild populations.J. Genet. 50, 174–8.
- Wright, S. (1934a). An analysis of variability in number of digits in an inbred strain of guinea pigs.Genetics,19, 506–36.
- Wright, S. (1934b). The results of crosses between inbred strains of guinea pigs, differing in number of digits.Genetics,19, 537–51.
- Genetical studies on the skeleton of the mouse
Journal of Genetics
Volume 51, Issue 1 , pp 95-114
- Cover Date
- Print ISSN
- Springer India
- Additional Links
- Hans Grüneberg (1)
- Author Affiliations
- 1. University College, London