, Volume 78, Issue 5, pp 439-442

MLL/AF-1p Fusion in Therapy-Related Early Pre-B Acute Lymphoblastic Leukemia with t(1;11)(p32;q23) Translocation Developing in the Relapse Phase of Acute Promyelocytic Leukemia

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We report the development of therapy-related early pre-B acute lymphoblastic leukemia in a patient administered a topoisomerase II inhibitor, etoposide, a consolidation therapy agent for acute promyelocytic leukemia. Our case is of interest because of simultaneous relapse of the original leukemia and onset of therapy-related leukemia and relatively rare t(1;11) (p32;q23) translocation with confirmedMLL/AF- 1p fusion. This case suggests that careful monitoring forMLL gene rearrangements is necessary after administration of topoisomerase II inhibitors.