International Journal of Hematology

, 78:208

Targeting Alloreactive Donor T-Cells to Hematopoietic System-Restricted Minor Histocompatibility Antigens to Dissect Graft-versus-Leukemia Effects from Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation

Progress in Hematology

DOI: 10.1007/BF02983796

Cite this article as:
Mutis, T. Int J Hematol (2003) 78: 208. doi:10.1007/BF02983796

Abstract

The graft-versus-leukemia (GVL) effect of HLA-identical allogeneic stem cell transplantation is mainly mediated by alloreactive T-cells directed at the minor histocompatibility antigens (H ags) expressed on the leukemic cells of the recipient. Minor H ags are major histocompatibility complex-bound polymorphic peptides that are derived from intracellular proteins and that can show ubiquitous or hematopoietic system-restricted expression. Whereas ubiquitous minor H ags are involved both in the GVL effect and in graft-versus-host disease (GVHD), hematopoietic system-specific minor H ags expressed on leukemic cells are considered important targets for leukemia-specific cellular immunotherapy with a low risk of GVHD. This review will summarize the current knowledge of the immunobiology of minor H ags and discuss the advantages and drawbacks of cellular immunotherapy strategies that aim to separate the GVL effect from GVHD by targeting donor T-cells to hematopoietic system-specific minor H ags.

Key words

Graft-versus-leukemia effectMinor histocompatibility antigensCellular immunotherapyGraft-versus-host diseaseLeukemia

Copyright information

© The Japanese Society of Hematology 2003

Authors and Affiliations

  1. 1.Department of HematologyUniversity Medical Center UtrechtUtrechtThe Netherlands