Antiproliferative Efficacy of the Third-Generation Bisphosphonate, Zoledronic Acid, Combined with Other Anticancer Drugs in Leukemic Cell Lines
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Bisphosphonates are widely used to treat bone diseases and appear to possess antitumor activity. Moreover, we recently found that a third-generation bisphosphonate, zoledronic acid (ZOL), synergistically interacts with imatinib in vitro and in vivo to induce antileukemic activity, and others have reported that ZOL interacts synergistically with paclitaxel. Thus, the efficacy of other antileukemic agents combined with ZOL should be evaluated experimentally. In this study, we investigated the effects of concurrent and sequential combinations of ZOL with several commonly used antileukemic agents, including imatinib, on the in vitro growth of leukemia cell lines. As a complement to our previous finding that ZOL synergistically augments the effects of imatinib, we report here that ZOL acts additively when administered concurrently with hydroxyurea (HU), cytarabine (Ara-C), or daunorubicin (DNR) in some leukemic cell lines. Furthermore, one day of ZOL pretreatment augmented the sensitivity of imatinib and Ara-C. Therefore, concurrent or sequential administration of ZOL with imatinib, HU, Ara-C, or DNR may increase the efficacy of leukemia treatment.
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- Antiproliferative Efficacy of the Third-Generation Bisphosphonate, Zoledronic Acid, Combined with Other Anticancer Drugs in Leukemic Cell Lines
International Journal of Hematology
Volume 79, Issue 1 , pp 37-43
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Zoledronic acid
- Combination therapy
- Industry Sectors
- Author Affiliations
- 1. Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, 54 Kawahara-cho Shogoin, 606-8507, Sakyo-ku, Kyoto, Japan
- 2. Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto
- 3. Department of Gastroenterology and Hematology, Shiga University of Medical Science, Otsu
- 4. Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
- 5. Department of Hematology, Johann Wolfgang Goethe University, Frankfurt, Germany