The Association of HLA Antigen and GVHD in Allogeneic Hemopoietic Stem Cell Transplantation with Histocompatible Sibling Donor: A Single-Center Experience in Korea

  • Hee Je Kim
  • Soo Jeong Park
  • Hyun Woo Im
  • Dong Wook Kim
  • Woo Sung Min
  • Hack Ki Kim
  • Won Il Kim
  • Kwang Sung Kim
  • Chun Choo Kim
Case Report

DOI: 10.1007/BF02982797

Cite this article as:
Kim, H.J., Park, S.J., Im, H.W. et al. Int J Hematol (2002) 76: 267. doi:10.1007/BF02982797

Abstract

We analyzed the association of HLA antigens with incidence of organ-specific graft-versus-host disease (GVHD) after allogeneic hemopoietic stem cell transplantation (allo-HSCT) from an HLA-matched sibling donor. We retrospectively reviewed the clinical records of allo-HSCT recipients and found 389 patients who had received matched-sibling HSCT. HLA types, GVHD grades, and the development of acute or chronic GVHD, factors that reflect a certain immunological impact associated with involved organs, were investigated. The overall incidence of acute and chronic GVHD was 24.8% (96 cases) and 21.2% (82 cases), respectively. The incidence of acute GVHD with grades II through IV was higher among patients who had HLA-B61 (P = .0153) and HLA-Cw3 (P = .0208). The donor sex (P = .0040) and the conditioning regimen (P = .0010) were also associated with severe acute GVHD.The extensive-type chronic GVHD incidence was higher in patients who had HLA-B54 (P = .0159).The donor sex (P = .0406) and the pretransplantation diagnosis (P = .0184) were other factors associated with the development of extensive-type chronic GVHD. Furthermore, HLA-B35 (P = .0226) and HLA-B54 (P = .0091) were associated with a higher incidence of severe acute skin GVHD and chronic skin and oral GVHD (in descending order of incidence rates). HLA-B7,27 was associated with chronic liver GVHD (P = .0476) in addition to other parameters including patient (P = .0246) and donor sex (P = .0019). This study shows that these remarkable HLA antigens may be potent transplantation immune regulators, but there is a need for further evaluation using larger study samples.

Key words

HSCTHLA antigensGVHDOrgan specificity

Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Hee Je Kim
    • 1
  • Soo Jeong Park
    • 1
  • Hyun Woo Im
    • 2
  • Dong Wook Kim
    • 1
  • Woo Sung Min
    • 1
  • Hack Ki Kim
    • 1
  • Won Il Kim
    • 3
  • Kwang Sung Kim
    • 4
  • Chun Choo Kim
    • 1
  1. 1.Catholic Hemopoietic Stem Cell Transplantation CenterSt. Mary’s Hospital, The Catholic University of KoreaSeoulKorea
  2. 2.Catholic Industrial Medical CenterThe Catholic University of KoreaSeoulKorea
  3. 3.Department of Clinical PathologyThe Catholic University of KoreaSeoulKorea
  4. 4.Catholic HSCTC CoordinatorThe Catholic University of KoreaSeoulKorea