International Journal of Hematology

, 74:76

Waldenström’s Macroglobulinemia Associated With AA Amyloidosis

  • J. Gardyn
  • A. Schwartz
  • R. Gal
  • U. Lewinski
  • D. Kristt
  • A. M. Cohen
Case Report

DOI: 10.1007/BF02982553

Cite this article as:
Gardyn, J., Schwartz, A., Gal, R. et al. Int J Hematol (2001) 74: 76. doi:10.1007/BF02982553

Abstract

It is widely accepted that amyloidosis in Waldenström’s macroglobulinemia (WM) is exclusively due to amyloid light-chain deposition. However, only a small number of previous reports have actually characterized the type of amyloid in WM.We now report the third patient with WM and amyloid A protein (AA) amyloidosis. This patient developed malabsorption, nephrotic syndrome, and orthostatic hypotension. AA was immunohistochemically demonstrated in the rectal biopsy. In conjunction with previous examples of AA amyloidosis, the present report raises the possibility that AA amyloidosis may also occur in WM patients.

Key words

Secondary amyloidosisWaldenström’s macroglobulinemiaNephrotic syndrome

Copyright information

© The Japanese Society of Hematology 2001

Authors and Affiliations

  • J. Gardyn
    • 1
  • A. Schwartz
    • 2
  • R. Gal
    • 2
  • U. Lewinski
    • 1
  • D. Kristt
    • 2
  • A. M. Cohen
    • 1
  1. 1.Hematology UnitPathology Institute, Golda-Hasharon Campus, Rabin Medical Center and Sackler School of Medicine, Tel-Aviv UniversityPetah-TikvaIsrael
  2. 2.Pathology Institute, Golda-Hasharon Campus, Rabin Medical Center and Sackler School of Medicine, Tel-Aviv UniversityPetah-TikvaIsrael
  3. 3.Hematology UnitGolda-Hasharon Campus, Rabin Medical CenterPetah-TikvaIsrael