Progress in hematology

International Journal of Hematology

, Volume 74, Issue 1, pp 9-17

First online:

Regulation of Hematopoiesis by Chemokine Family Members

  • Hal E. BroxmeyerAffiliated withDepartment of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine and the Walther Cancer Institute Email author 

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Chemokines, originally designated as chemoattractant cytokines, comprise a large family of molecules that have been implicated in a number of different functions mediated through chemokine receptors. Among these functions are regulatory roles in hematopoiesis that encompass effects on the proliferation, survival, and homing/migration of myeloid progenitor cells. This article reviews the field of chemokine regulation of hematopoiesis at the level of myeloid progenitor cells.

Key words

Chemokines Stem/progenitor cells Proliferation Survival Migration/homing