The rate of spontaneous mutation of a human gene
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- Haldane, J.B.S. Journ. of Genetics (1935) 31: 317. doi:10.1007/BF02982403
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The rate of mutation at which the gene for haemophilia appears in the population of London is estimated at about once in 50,000 human life cycles. There are probably two distinct allelomorphs at the same locus, the milder type arising less frequently by mutation than the severe type.