Journal of Genetics

, 31:317

The rate of spontaneous mutation of a human gene

  • J. B. S. Haldane

DOI: 10.1007/BF02982403

Cite this article as:
Haldane, J.B.S. Journ. of Genetics (1935) 31: 317. doi:10.1007/BF02982403


The rate of mutation at which the gene for haemophilia appears in the population of London is estimated at about once in 50,000 human life cycles. There are probably two distinct allelomorphs at the same locus, the milder type arising less frequently by mutation than the severe type.

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© Indian Academy of Sciences 1935

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  • J. B. S. Haldane

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