International Journal of Hematology

, Volume 73, Issue 1, pp 84–86

Elevated serum-soluble fas ligand in Histiocytic necrotizing lymphadenitis

Authors

    • First Department of PathologySchool of Medicine, Fukuoka University
  • Koichi Ohshima
    • First Department of PathologySchool of Medicine, Fukuoka University
  • Keizo Anzai
    • Department of Laboratory MedicineSchool of Medicine, Fukuoka University
  • Junji Suzumiya
    • First Department of PathologySchool of Medicine, Fukuoka University
  • Masahiro Kikuchia
    • First Department of PathologySchool of Medicine, Fukuoka University
Review Article

DOI: 10.1007/BF02981907

Cite this article as:
Kato, K., Ohshima, K., Anzai, K. et al. Int J Hematol (2001) 73: 84. doi:10.1007/BF02981907

Abstract

Recent studies have indicated that Fas and perforin-based mechanisms seem to induce apoptosis in histiocytic necrotizing lymphadenitis (HNL). In this study, we evaluated the serum levels of soluble Fas ligand (sFasL) in 30 HNL patients using paired sera. Elevations in sFasL levels were detected in 9 patients in the active stage. In the convalescent stage, the levels of sFasL decreased to an undetectable degree after 2 weeks.These findings indicate the possibility that sFasL plays an important role in the constitutional symptoms and pathogenesis of HNL and, furthermore, that it can act as a surrogate marker of the disease activity.

Key words

Histiocytic necrotizing lymphadenitisFas ligandSoluble Fas ligandPerforinApoptosis

Copyright information

© The Japanese Society of Hematology 2001