Review Article

International Journal of Hematology

, Volume 73, Issue 1, pp 84-86

First online:

Elevated serum-soluble fas ligand in Histiocytic necrotizing lymphadenitis

  • Kei KatoAffiliated withFirst Department of Pathology, School of Medicine, Fukuoka University Email author 
  • , Koichi OhshimaAffiliated withFirst Department of Pathology, School of Medicine, Fukuoka University
  • , Keizo AnzaiAffiliated withDepartment of Laboratory Medicine, School of Medicine, Fukuoka University
  • , Junji SuzumiyaAffiliated withFirst Department of Pathology, School of Medicine, Fukuoka University
  • , Masahiro KikuchiaAffiliated withFirst Department of Pathology, School of Medicine, Fukuoka University

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Abstract

Recent studies have indicated that Fas and perforin-based mechanisms seem to induce apoptosis in histiocytic necrotizing lymphadenitis (HNL). In this study, we evaluated the serum levels of soluble Fas ligand (sFasL) in 30 HNL patients using paired sera. Elevations in sFasL levels were detected in 9 patients in the active stage. In the convalescent stage, the levels of sFasL decreased to an undetectable degree after 2 weeks.These findings indicate the possibility that sFasL plays an important role in the constitutional symptoms and pathogenesis of HNL and, furthermore, that it can act as a surrogate marker of the disease activity.

Key words

Histiocytic necrotizing lymphadenitis Fas ligand Soluble Fas ligand Perforin Apoptosis