Archives of Pharmacal Research

, Volume 30, Issue 9, pp 1051–1054

Two new metabolites with cytotoxicities from deep-sea fungus, aspergillus sydowi YH11-2

Authors

  • Li Tian
    • First Institute of OceanographyState Oceanic Administration
  • Sheng-Xin Cai
    • Key laboratory of Marine Drugs, Chinese Ministry of Education; Institute of Marine Drugs and FoodOcean University of China
  • De-Hai Li
    • Key laboratory of Marine Drugs, Chinese Ministry of Education; Institute of Marine Drugs and FoodOcean University of China
  • Zhen-Jian Lin
    • Key laboratory of Marine Drugs, Chinese Ministry of Education; Institute of Marine Drugs and FoodOcean University of China
  • Tian-Jiao Zhu
    • Key laboratory of Marine Drugs, Chinese Ministry of Education; Institute of Marine Drugs and FoodOcean University of China
  • Yu-Chun Fang
    • Key laboratory of Marine Drugs, Chinese Ministry of Education; Institute of Marine Drugs and FoodOcean University of China
  • Pei-Pei Liu
    • Key laboratory of Marine Drugs, Chinese Ministry of Education; Institute of Marine Drugs and FoodOcean University of China
    • Key laboratory of Marine Drugs, Chinese Ministry of Education; Institute of Marine Drugs and FoodOcean University of China
    • Key laboratory of Marine Drugs, Chinese Ministry of Education; Institute of Marine Drugs and FoodOcean University of China
Article Drug discovery

DOI: 10.1007/BF02980236

Cite this article as:
Tian, L., Cai, S., Li, D. et al. Arch Pharm Res (2007) 30: 1051. doi:10.1007/BF02980236

Abstract

Two new compounds, 2, 3, 5-trimethyl-6-(3-oxobutan-2-yl)-4H-pyran-4-one (1) and (2R)-2, 3-dihydro-7-hydroxy-6, 8-dimethyl-2-[(E)-prop-1-enyl] chromen-4-one (2), together with six known compounds (3–8), were isolated from a deep-sea fungus, identified as Aspergillus sydowi, by a bioassay-guided method. Their structures were elucidated by spectroscopic methods and the cytotoxicities were evaluated by SRB method.

Key words

Deep-sea (depth 1000 m)Aspergillus sydowiMetaboliteCytotoxicities

Copyright information

© The Pharmaceutical Society of Korea 2007