Archives of Pharmacal Research

, Volume 27, Issue 7, pp 730–733

Triterpenoid saponin fromviola hondoensis W. Becker et H Boss. and their effect on mmp-1 and type i procollagen expression

Authors

    • Department of DermatologySeoul National University College of Medicine, and Clinical research Institute, Seoul National University Hosipital
    • College of PharmacySung Kyun Kwan University
    • Department of DermatologySeoul National University College of Medicine, and Clinical research Institute, Seoul National University Hosipital
  • Joong-Ku Lee
    • Korea Research Institute of Bioscience and Biotechnology
  • Ok-Pyo Zee
    • College of PharmacySung Kyun Kwan University
Research Articles Articles

DOI: 10.1007/BF02980140

Cite this article as:
Moon, H., Chung, J.H., Lee, J. et al. Arch Pharm Res (2004) 27: 730. doi:10.1007/BF02980140

Abstract

Bioassay-guided fractionation has led to the isolation of triterpenoid saponins such as Acutoside A (3-O-[O-β-D-glucopyranosyl-(1→2)-O-β-D-glucopyranosyl] oleanolic acid) from the whole plants ofViola hondoensis. Among them, Saponin 1 exhibited potent inhibitory activity against matrix metalloproteinase (MMP)-1, and prevented the UV-induced changes in the MMP-1 expression. In addition, compound was isolated from this plant for the first time.

Key words

Viola hondoensisViolaceaeTriterpenoid saponinMMP1 inhibitor

Copyright information

© The Pharmaceutical Society of Korea 2004