Archives of Pharmacal Research

, Volume 27, Issue 7, pp 730–733

Triterpenoid saponin fromviola hondoensis W. Becker et H Boss. and their effect on mmp-1 and type i procollagen expression

Research Articles Articles

DOI: 10.1007/BF02980140

Cite this article as:
Moon, HI., Chung, J.H., Lee, JK. et al. Arch Pharm Res (2004) 27: 730. doi:10.1007/BF02980140


Bioassay-guided fractionation has led to the isolation of triterpenoid saponins such as Acutoside A (3-O-[O-β-D-glucopyranosyl-(1→2)-O-β-D-glucopyranosyl] oleanolic acid) from the whole plants ofViola hondoensis. Among them, Saponin 1 exhibited potent inhibitory activity against matrix metalloproteinase (MMP)-1, and prevented the UV-induced changes in the MMP-1 expression. In addition, compound was isolated from this plant for the first time.

Key words

Viola hondoensisViolaceaeTriterpenoid saponinMMP1 inhibitor

Copyright information

© The Pharmaceutical Society of Korea 2004

Authors and Affiliations

  1. 1.Department of DermatologySeoul National University College of Medicine, and Clinical research Institute, Seoul National University HosipitalSeoulKorea
  2. 2.Korea Research Institute of Bioscience and BiotechnologyDaejeonKorea
  3. 3.College of PharmacySung Kyun Kwan UniversitySuwonKorea