Archives of Pharmacal Research

, Volume 27, Issue 2, pp 194–198

Inhibitory phlorotannins from the edible brown algaecklonia stolonifera on total reactive oxygen species (ROS) generation

  • Hye Sook Kang
  • Hae Young Chung
  • Ji Young Kim
  • Byeng Wha Son
  • Hyun Ah Jung
  • Jae Sue Choi
Research Articles Articles

DOI: 10.1007/BF02980106

Cite this article as:
Kang, H.S., Chung, H.Y., Kim, J.Y. et al. Arch Pharm Res (2004) 27: 194. doi:10.1007/BF02980106

Abstract

Reactive oxygen species (ROS) play an important role in the pathogenesis of many human degenerative diseases such as cancer, aging, arteriosclerosis, and rheumatism. Much attention has been focused on the development of safe and effective antioxidants. To discover sources of antioxidative activity in marine algae, extracts from 17 kinds of seaweed were screened for their inhibitory effect on total ROS generation in kidney homogenate using 2′,7′-dichlorofluorescein diacetate (DCFH-DA). ROS inhibition was seen in three species:Ulva pertusa, Symphyocladia latiuscula, andEcklonia stolonifera. At a final concentration of 25 μg/mL,U. pertusa inhibited 85.65±20.28% of total ROS generation,S. latiscula caused 50.63±0.09% inhibitory, and theEcklonia species was 44.30±7.33% inhibition.E. stolonifera Okamura (Laminariaceae), which belongs to the brown algae, has been further investigated because it is commonly used as a foodstuff in Korea. Five compounds, phloroglucinol (1), eckstolonol (2), eckol (3), phlorofucofuroeckol A (4), and dieckol (5), isolated from the ethyl acetate soluble fraction of the methanolic extract ofE. stolonifera inhibited total ROS generation.

Key words

Ecklonia stolonifera Phlorotannins Total ROS Antioxidant 

Copyright information

© The Pharmaceutical Society of Korea 2004

Authors and Affiliations

  • Hye Sook Kang
    • 1
  • Hae Young Chung
    • 2
  • Ji Young Kim
    • 2
  • Byeng Wha Son
    • 3
  • Hyun Ah Jung
    • 4
  • Jae Sue Choi
    • 1
  1. 1.Faculty of Food Science and BiotechnologyPukyong National UniversityBusanKorea
  2. 2.College of PharmacyPusan National UniversityBusanKorea
  3. 3.Department of ChemistryPukyong National UniversityBusanKorea
  4. 4.Korea Maritime UniversityBusanKorea

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