Research Articles Articles

Archives of Pharmacal Research

, Volume 27, Issue 2, pp 164-168

Pytochemical constituents of the aerial parts fromsolidago virga-aurea var. gigantea

  • Sang Zin ChoiAffiliated withNatural Products Laboratory, College of Pharmacy, SungKyunKwan University
  • , Sang Un ChoiAffiliated withKorea Research Institute of Chemical Technology
  • , Kang Ro LeeAffiliated withNatural Products Laboratory, College of Pharmacy, SungKyunKwan University Email author 

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The chromatographic separation of the MeOH extract of the aerial parts of Solidago virgaaurea var. gigantea MIQ. (Compositae) led to the isolation of six terpenoids and four phenolic compounds,frans-phytol (1),ent-germacra-4(15),5,10(14)-trien-1-ol (2), β-amyrin acetate (3),ent-germacra-4(15),5,10(14)-trien-1β-ol (4), β-dictyopterol (5), oleanolic acid (6), kaempferol (7), kaempferol-3-O-rutinoside (8), methyl 3,5-di-O-caffeoyl quinate (9), and 3,5-di-O-caffeoyl quinic acid (10). Their structures were established by chemical and spectroscopic methods. Compounds4,5, and10 showed moderate cytotoxicity against five cultured human tumor cell lines in vitro with its ED50 values ranging from 1.52~18.57 μg/mL

Key words

Solidago virga-aurea var.gigantea MlQ Compositae, Terpenoid Flavonoid Quinic acid Cytotoxicity