Archives of Pharmacal Research

, Volume 27, Issue 2, pp 164–168

Pytochemical constituents of the aerial parts fromsolidago virga-aurea var. gigantea

Research Articles Articles

DOI: 10.1007/BF02980100

Cite this article as:
Choi, S.Z., Choi, S.U. & Lee, K.R. Arch Pharm Res (2004) 27: 164. doi:10.1007/BF02980100


The chromatographic separation of the MeOH extract of the aerial parts of Solidago virgaaurea var. gigantea MIQ. (Compositae) led to the isolation of six terpenoids and four phenolic compounds,frans-phytol (1),ent-germacra-4(15),5,10(14)-trien-1-ol (2), β-amyrin acetate (3),ent-germacra-4(15),5,10(14)-trien-1β-ol (4), β-dictyopterol (5), oleanolic acid (6), kaempferol (7), kaempferol-3-O-rutinoside (8), methyl 3,5-di-O-caffeoyl quinate (9), and 3,5-di-O-caffeoyl quinic acid (10). Their structures were established by chemical and spectroscopic methods. Compounds4,5, and10 showed moderate cytotoxicity against five cultured human tumor cell lines in vitro with its ED50 values ranging from 1.52~18.57 μg/mL

Key words

Solidago virga-aurea var.gigantea MlQCompositae, TerpenoidFlavonoidQuinic acidCytotoxicity

Copyright information

© The Pharmaceutical Society of Korea 2004

Authors and Affiliations

  1. 1.Natural Products Laboratory, College of PharmacySungKyunKwan UniversitySuwon, Kyunggi-DoKorea
  2. 2.Korea Research Institute of Chemical TechnologyDaejeonKorea
  3. 3.Natural Products Laboratory, College of PharmacySungKyunKwan UniversityJangan-ku, SuwonKorea