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Archives of Pharmacal Research

, Volume 22, Issue 5, pp 520-523

First online:

HIV integrase inhibitory activity ofAgastache rugosa

  • Hye Kyong KimAffiliated withResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University
  • , Hyeong-Kyu LeeAffiliated withKorea Research Institute of Bioscience and Biotechnology, KIST
  • , Cha-Gyun ShinAffiliated withDepartment of Biotechnology, Chung-Ang University
  • , Hoon HuhAffiliated withResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University Email author 

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Abstract

We have been screening anti-HIV integrase compounds from Korean medicinal plants by using anin vitro assay system which is mainly composed of recombinant human immunodeficency virus type 1 integrase and radiolabeled oligonucleotides. From the above screening, the aqueous methanolic extract of the roots ofAgastache rugosa exhibited a significant activity. Bioactivity-guided chromatographic fractionation of the methanolic extract resulted in the isolation of rosmarinic acid. The structure of the compound was determined by spectroscopic data and by the comparison with the reported values. The IC50 of the rosmarinic acid was approximately 10 μ/ml against HIV integrase.

Key words

HIV integrase Agastache rugosa Labiatae Rosmarinic acid