Archives of Pharmacal Research

, Volume 22, Issue 4, pp 417–422

Two new lignans fromLindera obtusiloba blume

Authors

  • Hak Cheol Kwon
    • Natural Products Laboratory, College of PharmacySung Kyun Kwan University
  • Sang Un Choi
    • Korea Research Institute of Chemical Technology
  • Jung Ock Lee
    • Korea Research Institute of Chemical Technology
  • Ki Hwan Bae
    • College of PharmacyChungnam National University
  • Ok Pyo Zee
    • Natural Products Laboratory, College of PharmacySung Kyun Kwan University
    • Natural Products Laboratory, College of PharmacySung Kyun Kwan University
Research Articles Natural Products

DOI: 10.1007/BF02979069

Cite this article as:
Kwon, H.C., Choi, S.U., Lee, J.O. et al. Arch Pharm Res (1999) 22: 417. doi:10.1007/BF02979069

Abstract

Two new furanolignans (3, 5), together with three known lignans (1, 2, 4), were isolated from the stem ofLindera obtusiloba (Lauraceae). The structures of the compounds were determined as actifolin (1), pluviatilol (2), 5,6-dihydroxymatairesinol (3), (+)-syringaresinol (4), and (+)-9′-O-trans-feruloyl-5,5′-dimethoxylariciresinol (5) on the basis of physicochemical and spectroscopic evidences. Compounds1, 2, 3, and5 showed cytotoxicity against a small panel of human tumor cell lines with ED50 values of 3.40∼19.27 μg/ml.

Key words

Lindera obtusilobaLauraceaeCytotoxicityLignanActifolinPluviatilol

Copyright information

© The Pharmaceutical Society of Korea 1999