, Volume 28, Issue 9, pp 1031-1036

Antimicrobial property of (+)-lyoniresinol-3α-O-β-d-Glucopyranoside isolated from the root bark ofLycium chinense Miller against human pathogenic microorganisms

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Abstract

(+)-Lyoniresinol-3α-O-β-d-glucopyranoside (1) was isolated from an ethyl acetate extract of the root bark fromLycium chinense Miller, and its structure was determined using 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC. (+)-Lyoniresinol-3α-O-β-d-glucopyranoside exhibited potent antimicrobial activity against antibiotic-resistant bacterial strains, methicillinresistantStaphylococcus aureus (MRSA) isolated from patients, and human pathogenic fungi without having any hemolytic effect on human erythrocytes. In particular, compound1 induced the accumulation of intracellular trehalose onC. albicans as stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae caused by the pathogenesis. This indicates that (+)-lyoniresinol-3α-O-β-d-glucopyranoside has excellent potential as a lead compound for the development of antibiotic agents.