Archives of Pharmacal Research

, Volume 25, Issue 6, pp 747–758

Biological significance of essential fatty acids/prostanoids/ lipoxygenase-derived monohydroxy fatty acids in the skin

Research Article Review

DOI: 10.1007/BF02976988

Cite this article as:
Ziboh, V.A., Cho, Y., Mani, I. et al. Arch Pharm Res (2002) 25: 747. doi:10.1007/BF02976988


The skin displays a highly active metabolism of polyunsaturated fatty acids (PUFA). Dietary deficiency of linoleic acid (LA), an 18-carbon (n-6) PUFA, results in characteristic scaly skin disorder and excessive epidermal water loss. Although arachidonic acid (AA), a 20-carbon (n-6) PUFA, is metabolized via cyclooxygenase pathway into predominantly prostaglandin E2 (PGE2) and PGF, the metabolism of AA via the 15-lipoxygenase (15-LOX) pathway, which is very active in skin epidermis and catalyzes the transformation of AA into predominantly 15S-hydroxyeicosatetraenoic acid (15S-HETE). Additionally, the 15-LOX also metabolizes the 18-carbon LA into 13S-hydroxyoctadecadienoic acid (13S-HODE), respectively. Interestingly, 15-LOX catalyzes the transformation of dihomo-γ-linolenic acid (DGLA), derived from dietary gamma-linolenic acid, to 15S-hydroxyeicosatrienoic acid (15S-HETrE). These monohydroxy fatty acids are incorporated into the membrane inositol phospholipids which undergo hydro-lytic cleavage to yield substituted-diacylglycerols such as 13S-HODE-DAG from 13S-HODE and 15S-HETrE-DAG from 15S-HETrE. These substituted-monohydroxy fatty acids seemingly exert anti-inflammatory/antiproliferative effects via the modulation of selective protein kinase C as well as on the upstream/down-stream nuclear MAP-kinase/AP-1/apoptotic signaling events.


Fatty acids Prostanoids Lipoxygenase Epidermal proliferation 15S-HETE 15S-HETrE PUFA Linoleic acid 13S-HODE Cell signal PKC Skin Cox-2 

Copyright information

© The Pharmaceutical Society of Korea 2002

Authors and Affiliations

  • Vincent A. Ziboh
    • 1
  • Yunhi Cho
    • 1
  • Indu Mani
    • 1
  • Side Xi
    • 1
  1. 1.Department of DermatologyUniversity of California DavisDavisUSA
  2. 2.Department of Dermatology TB 192University of California DavisDavis

Personalised recommendations