Research Articles

Archives of Pharmacal Research

, Volume 21, Issue 6, pp 744-748

First online:

Synthesis of praziquantel derivatives and theirin vitro activity against adultClonorchis sinensis

  • Choong Sup KimAffiliated withDivision of Applied Science, Korea Institute of Science & Technology
  • , Duk Young MinAffiliated withDepartment of Parasitology, College of Medicine, Hanyang University

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Several praziquantel derivatives have been prepared by the acylation of compound5, and examined on their biological activityin vitro against adultClonorchis sinensis collected from rabbits infected with metacercariae which was isolated fromPseudorasbora parva, a second intermediate host, captured in Nakdong river in Korea.

Key words

Praziquantel derivatives Anthelmintic activity Clonorchis sinensis