, Volume 21, Issue 6, pp 744-748

Synthesis of praziquantel derivatives and theirin vitro activity against adultClonorchis sinensis

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Abstract

Several praziquantel derivatives have been prepared by the acylation of compound5, and examined on their biological activityin vitro against adultClonorchis sinensis collected from rabbits infected with metacercariae which was isolated fromPseudorasbora parva, a second intermediate host, captured in Nakdong river in Korea.