Archives of Pharmacal Research

, Volume 27, Issue 9, pp 919–922

Induction of the anticarcinogenic marker enzyme, quinone reductase, by Dalbergiae Lignum

  • Hu-Quan Yin
  • Bang-Wool Lee
  • Youn-Chul Kim
  • Dong-Hwan Sohn
  • Byung-Hoon Lee
Research Article Article

DOI: 10.1007/BF02975844

Cite this article as:
Yin, H., Lee, B., Kim, Y. et al. Arch Pharm Res (2004) 27: 919. doi:10.1007/BF02975844

Abstract

The effect of an extract of Dalbergiae Lignum and four components that were isolated from the extract on the anticarcinogenic phase II marker enzyme, quinone reductase (QR), was investigated. Of the solvent extracts of Dalbergiae Lignum, the CH2Cl2 fraction was the most potent in inducing QR activity, with a CD value (the concentration required to double the QR activity) of 29.5 μg/mL. The CH2Cl2 extract was further separated into six compounds, four of which were identified as 4-methoxydalbergione, latifolin, 4’,6-dihydroxy-7-methoxyflavanone, and obtusafuran. Obtusafuran [CD = 1.1 μM; chemopreventive index (Cl) = 101.9] and latifolin (CD = 1.7 μM; Cl = 154.6) displayed potent QR inducing activity and high chemopreventive indices. Latifolin and 4-methoxydalbergione were identified as strong DPPH-scavengers with half-maximal free radical scavenging concentrations of 15.9 and 17.2 μM, respectively.

Key words

Dalbergiae lignumObtusafuranLatifolinQuinone reductaseDPPHChemoprevention

Copyright information

© The Pharmaceutical Society of Korea 2004

Authors and Affiliations

  • Hu-Quan Yin
    • 1
  • Bang-Wool Lee
    • 1
  • Youn-Chul Kim
    • 1
  • Dong-Hwan Sohn
    • 1
  • Byung-Hoon Lee
    • 1
  1. 1.College of Pharmacy and MeRRIWonkwang UniversityIksan, JeonbukKorea