, Volume 22, Issue 6, pp 642-645

Anti-allergic components from the peels ofCitrus unshiu

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Abstract

In a bioassay-guided search for anti-allergic compounds from higher plants of Korea, polymethoxyflavones, 3′,4′,5,6,7,8-hexamethoxyflavone (I), 5-hydroxy-3′,4′,6,7,8-pentamethoxyflavone (II) and 3′,4′,5,7,8,-pentamethoxyflavone (III) have been isolated from the immature peels ofCitrus unshiu. Structures of these compounds were elucidated on the basis of spectroscopic techniques. CompoundsI andII inhibited dose-dependently histamine release from the rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE.