Archives of Pharmacal Research

, Volume 22, Issue 6, pp 642–645

Anti-allergic components from the peels ofCitrus unshiu

  • Dae Keun Kim
  • Ki Taek Lee
  • Jae Soon Eun
  • Ok Pyo Zee
  • Jong Pil Lim
  • Sang Sup Eum
  • Sang Hyun Kim
  • Tae Yong Shin
Research Articles Natural Products

DOI: 10.1007/BF02975340

Cite this article as:
Kim, D.K., Lee, K.T., Eun, J.S. et al. Arch Pharm Res (1999) 22: 642. doi:10.1007/BF02975340
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Abstract

In a bioassay-guided search for anti-allergic compounds from higher plants of Korea, polymethoxyflavones, 3′,4′,5,6,7,8-hexamethoxyflavone (I), 5-hydroxy-3′,4′,6,7,8-pentamethoxyflavone (II) and 3′,4′,5,7,8,-pentamethoxyflavone (III) have been isolated from the immature peels ofCitrus unshiu. Structures of these compounds were elucidated on the basis of spectroscopic techniques. CompoundsI andII inhibited dose-dependently histamine release from the rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE.

Key words

Anti-allergic effectCitrus unshiu3′,4′,5,6,7,8-Hexamethoxyflavone5-Hydroxy-3′,4′,6,7,8-pentamethoxyflavoneCompound 48/80Anti-DNP IgE

Copyright information

© The Pharmaceutical Society of Korea 1999

Authors and Affiliations

  • Dae Keun Kim
    • 1
  • Ki Taek Lee
    • 1
  • Jae Soon Eun
    • 1
  • Ok Pyo Zee
    • 2
  • Jong Pil Lim
    • 1
  • Sang Sup Eum
    • 1
  • Sang Hyun Kim
    • 1
  • Tae Yong Shin
    • 1
  1. 1.College of PharmacyWoosuk UniversitySamryeKorea
  2. 2.College of PharmacySung Kyun Kwan UniversitySuwonKorea