Research Article Medicinal Chemistry & Natural Products

Archives of Pharmacal Research

, Volume 24, Issue 6, pp 514-517

Virus-cell fusion inhibitory activity for the polysaccharides from various Korean edible clams

  • Eun-Rhan WooAffiliated withCollege of Pharmacy, Chosun University Email author 
  • , Wan Seok KimAffiliated withNatural Products Research Institute, Seoul National University
  • , Yeong Shik KimAffiliated withNatural Products Research Institute, Seoul National University

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In order to find potent virus-cell fusion inhibitory components from Korean edible clams, thirteen prepared polysaccharides were introduced to syncytia formation inhibition assay, which is based on the interaction between the HIV-1 envelope protein gp120/41 and the cellular membrane protein CD4 of T lymphocytes. Among them,Meretrix petechialis showed a potent viruscell fusion inhibitory activity. Fusion index (FI) and percent (%) fusion inhibition of the polysaccharide of this clam were 0.21 ±0.02, and 67.52±4.09 at 100μg/ml, respectively. It exhibited almost equivalent virus-cell fusion inhibitory activity to that of dextran sulfate which was used as a standard control.

Key words

Anti-HIV gp120/41 Syncytia Fusion Clams