Studies of structure activity relationship of flavonoids for the anti-allergic actions
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- Cheong, H., Ryu, S., Oak, M. et al. Arch. Pharm. Res. (1998) 21: 478. doi:10.1007/BF02974647
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The structure activity relationship of flavonoids for anti-allergic actions was studied by determining the IC50 values for the degranulation. The hexosaminidase release from RBL-2H3 cells (degranulation marker) was employed as an estimate for the anti-allergic actions. Among 22 flavonoid compounds tested, luteolin, apigenin, diosmetin, fisetin, and quercetin were found to be most active with IC50 values less than 10 μM.