Archives of Pharmacal Research

, Volume 21, Issue 2, pp 147–152

Synthesis andin vitro cytotoxicity of cinnamaldehydes to human solid tumor cells

Authors

  • Byoung-Mog Kwon
    • Korea Research Institute of Bioscience & BiotechnologyProtein Regulator RU
  • Seung-Ho Lee
    • Korea Research Institute of Bioscience & BiotechnologyProtein Regulator RU
  • Sang Un Choi
    • Pharmaceutical Screening Lab.Korea Research Institute of Chemical Technology
  • Sung Hee Park
    • Pharmaceutical Screening Lab.Korea Research Institute of Chemical Technology
  • Chong Ock Lee
    • Pharmaceutical Screening Lab.Korea Research Institute of Chemical Technology
  • Young-Kwon Cho
    • Department of Agricultural ChemistryChoongnam National University
  • Nack-Do Sung
    • Department of Agricultural ChemistryChoongnam National University
  • Song-Hae Bok
    • Korea Research Institute of Bioscience & BiotechnologyProtein Regulator RU
Research Articles

DOI: 10.1007/BF02974019

Cite this article as:
Kwon, B., Lee, S., Choi, S.U. et al. Arch. Pharm. Res. (1998) 21: 147. doi:10.1007/BF02974019

Abstract

Cinnamaldehydes and related compounds were synthesized from various cinnamic acids based on the 2′-hydroxycinnamaldehyde isolated from the bark ofCinnamomum cassia Blume. The cytotoxicity to human solid tumor cells such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT15 were measured. Cinnamic acid, cinnamates and cinnamyl alcohols did not show any cytotoxicity against the human tumor cells. Cinnamaldehydes and realted compounds were resistant to A549 cell line up to 15 μg/ml. In contrast, HCT15 and SK-MEL-2 cells were much sensitive to these cinnamaldehyde analogues which showed ED50 values 0.63-8.1 μg/ml. Cytotoxicity of the saturated aldehydes was much weak compared to their unsaturated aldehydes. From these studies, it was found that the key functional group of the cinnamaldehyde-related compounds in the antitumor activity is the propenal group.

Key words

CinnamaldehydeHuman tumor cellCytotoxicityCinnamomum cassia

Copyright information

© The Pharmaceutical Society of Korea 1998