Research Articles

Archives of Pharmacal Research

, Volume 21, Issue 2, pp 147-152

Synthesis andin vitro cytotoxicity of cinnamaldehydes to human solid tumor cells

  • Byoung-Mog KwonAffiliated withKorea Research Institute of Bioscience & Biotechnology, Protein Regulator RU
  • , Seung-Ho LeeAffiliated withKorea Research Institute of Bioscience & Biotechnology, Protein Regulator RU
  • , Sang Un ChoiAffiliated withPharmaceutical Screening Lab., Korea Research Institute of Chemical Technology
  • , Sung Hee ParkAffiliated withPharmaceutical Screening Lab., Korea Research Institute of Chemical Technology
  • , Chong Ock LeeAffiliated withPharmaceutical Screening Lab., Korea Research Institute of Chemical Technology
  • , Young-Kwon ChoAffiliated withDepartment of Agricultural Chemistry, Choongnam National University
  • , Nack-Do SungAffiliated withDepartment of Agricultural Chemistry, Choongnam National University
  • , Song-Hae BokAffiliated withKorea Research Institute of Bioscience & Biotechnology, Protein Regulator RU

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Abstract

Cinnamaldehydes and related compounds were synthesized from various cinnamic acids based on the 2′-hydroxycinnamaldehyde isolated from the bark ofCinnamomum cassia Blume. The cytotoxicity to human solid tumor cells such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT15 were measured. Cinnamic acid, cinnamates and cinnamyl alcohols did not show any cytotoxicity against the human tumor cells. Cinnamaldehydes and realted compounds were resistant to A549 cell line up to 15 μg/ml. In contrast, HCT15 and SK-MEL-2 cells were much sensitive to these cinnamaldehyde analogues which showed ED50 values 0.63-8.1 μg/ml. Cytotoxicity of the saturated aldehydes was much weak compared to their unsaturated aldehydes. From these studies, it was found that the key functional group of the cinnamaldehyde-related compounds in the antitumor activity is the propenal group.

Key words

Cinnamaldehyde Human tumor cell Cytotoxicity Cinnamomum cassia