Original Article

Breast Cancer

, Volume 9, Issue 3, pp 216-219

P63 expression in normal, hyperplastic and malignant breast tissues

  • Xiaojuan WangAffiliated withDepartment of Pathology, Wakayama Medical University Email author 
  • , Ichiro MoriAffiliated withDepartment of Pathology, Wakayama Medical University
  • , Weihua TangAffiliated withDepartment of Pathology, Wakayama Medical University
  • , Misa NakamuraAffiliated withDepartment of Pathology, Wakayama Medical University
  • , Yasushi NakamuraAffiliated withDepartment of Pathology, Wakayama Medical University
  • , Misako SatoAffiliated withDepartment of Pathology, Wakayama Medical University
  • , Takeo SakuraiAffiliated withDepartment of Surgery, Kihoku Affiliated Hospital, Wakayama Medical University
  • , Kennichi KakudoAffiliated withDepartment of Pathology, Wakayama Medical University

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Abstract

Background

p63 is a homologue of the p53 tumor suppressor gene and its protein is selectively expressed in the basal cells of a variety of epithelial tissues. It has recently been confirmed that p63 is expressed in the basal cells of normal prostate glands but not in prostatic carcinomas. Whether expression of p63 in breast correlates with tumor progression is the focus of this study.

Methods

Forty cases, which all contained normal breast tissue, ductal hyperplasia, ductal carcinomain situ and invasive ductal carcinoma in the same patient were included in this investigation using an indirect immunohistochemical method and double staining.

Results

p63 was exclusively expressed in the myoepithelial cells of normal breast, partially expressed in ductal hyperplasia, rarely expressed in carcinomain situ and not expressed in invasive carcinomas.

Conclusions

The results suggest an association between loss of p63 expression and progression of breast ductal carcinoma. p63 immunostaining might be of assistance for distinguishing invasive ductal carcinoma from ductal carcinomain situ or rare questionable ductal hyperplastic lesions, leading to correct therapy clinically.

Key words

p63 Ductal intraepithelial neoplasia Intraductal hyperplasia Atypical ductal hyperplasia Ductal carcinomain situ Breast cancer Immunohistochemistry