Breast Cancer

, Volume 7, Issue 1, pp 33–36

Human papillomavirus type 33 dna in breast cancer in Chinese

  • Yingyan Yu
  • Tadaoki Morimoto
  • Mitsunori Sasa
  • Kuniyasu Okazaki
  • Yosuke Harada
  • Tsutomu Fujiwara
  • Yasuo Irie
  • Ei-ichi Takahashi
  • Akira Tanigami
  • Keisuke Izumi
Original Article

DOI: 10.1007/BF02967185

Cite this article as:
Yu, Y., Morimoto, T., Sasa, M. et al. Breast Cancer (2000) 7: 33. doi:10.1007/BF02967185

Abstract

Background

The association between human papillomavirus (HPV) and anogenital tumors, especially cervical cancer, is well documented. However, it remains unclear whether there is also a correlation between HPV infection and human breast cancer.

Methods

We used PCR and Southern blot hybridization to analyze HPV-related DNA specimens from 32 cases of invasive ductal carcinoma operated upon in the Shanghai region of China.

Results

DNA derived from HPV33 was detected in 14 cases (43.8%). No HPV16 or HPV18 DNA was detected in any of the cases in this study. This is the first report demonstrating a correlation between HPV33 infection and breast cancer.

Conclusions

Our results suggest that HPV33 infection may be involved in the pathogenesis of breast cancer in Chinese.

Key words

HPV33Breast cancerPCRChinese

Abbreviations

HPV

Human papillomavirus

DNA

Deoxyribonucleic acid

PCR

Polymerase chain reaction

G3PDH

Glyceraldehyde 3-phosphate dehydrogenase

Copyright information

© The Japanese Breast Cancer Society 2000

Authors and Affiliations

  • Yingyan Yu
    • 1
    • 2
  • Tadaoki Morimoto
    • 2
  • Mitsunori Sasa
    • 3
  • Kuniyasu Okazaki
    • 4
  • Yosuke Harada
    • 5
  • Tsutomu Fujiwara
    • 5
  • Yasuo Irie
    • 5
  • Ei-ichi Takahashi
    • 5
  • Akira Tanigami
    • 5
  • Keisuke Izumi
    • 6
  1. 1.Department of PathologyShanghai First People’s HospitalChina
  2. 2.The University of Tokushima, School of Medical SciencesJapan
  3. 3.Tokushima Breast Care ClinicJapan
  4. 4.Kunitomi Surgical Clinic of OkayamaJapan
  5. 5.Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, LtdJapan
  6. 6.2nd Department of PathologyThe University of Tokushima, School of MedicineJapan
  7. 7.The University of Tokushima, School of Medical SciencesTokushimaJapan