Original Article

Breast Cancer

, Volume 7, Issue 1, pp 33-36

First online:

Human papillomavirus type 33 dna in breast cancer in Chinese

  • Yingyan YuAffiliated withDepartment of Pathology, Shanghai First People’s HospitalThe University of Tokushima, School of Medical Sciences
  • , Tadaoki MorimotoAffiliated withThe University of Tokushima, School of Medical Sciences
  • , Mitsunori SasaAffiliated withTokushima Breast Care Clinic
  • , Kuniyasu OkazakiAffiliated withKunitomi Surgical Clinic of Okayama
  • , Yosuke HaradaAffiliated withOtsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd
  • , Tsutomu FujiwaraAffiliated withOtsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd
  • , Yasuo IrieAffiliated withOtsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd
  • , Ei-ichi TakahashiAffiliated withOtsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd
  • , Akira TanigamiAffiliated withOtsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd
    • , Keisuke IzumiAffiliated with2nd Department of Pathology, The University of Tokushima, School of Medicine

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Abstract

Background

The association between human papillomavirus (HPV) and anogenital tumors, especially cervical cancer, is well documented. However, it remains unclear whether there is also a correlation between HPV infection and human breast cancer.

Methods

We used PCR and Southern blot hybridization to analyze HPV-related DNA specimens from 32 cases of invasive ductal carcinoma operated upon in the Shanghai region of China.

Results

DNA derived from HPV33 was detected in 14 cases (43.8%). No HPV16 or HPV18 DNA was detected in any of the cases in this study. This is the first report demonstrating a correlation between HPV33 infection and breast cancer.

Conclusions

Our results suggest that HPV33 infection may be involved in the pathogenesis of breast cancer in Chinese.

Key words

HPV33 Breast cancer PCR Chinese