Elevated serum concentrations of soluble selectin and immunoglobulin type adhesion molecules in patients with inflammatory bowel disease
Received: 18 March 1996 Accepted: 20 December 1996 DOI:
Cite this article as: Göke, M., Hoffmann, J.C., Evers, J. et al. J Gastroenterol (1997) 32: 480. doi:10.1007/BF02934086 Abstract
Adhesion molecules mediate the extravasation of leukocytes and their accumulation in inflamed tissues. In the present study, serum concentrations of the selectin (sP- and sE-selectin) and immunoglobulin supergene family (sICAM-1 and sVCAM-1) of adhesion molecules were measured in 93 patients with inflammatory bowel disease (Crohn's disease,
n=65; ulcerative colitis, n=28) and 58 age-matched normal controls. sP-selectin serum concentrations (mean ±SEM ng/ml) of patients with Crohn's disease (399 ±33 ng/ml) and ulcerative colitis (385 ± 42 ng/ml) were increased ( P=0.0067 and P=0.0193, respectively) compared to controls (251±33 ng/ml). In contrast, E-selectin serum levels of patients with Crohn's disease (58±5 ng/ml) and ulcerative colitis (64±12 ng/ml) were not significantly higher than those of controls (53±5 ng/ml). sICAM-1 serum concentrations of patients with Crohn's disease (420±19 ng/ml) and those with ulcerative colitis (375±40 ng/ml) were elevated ( P=0.0001 and P=0.0473, respectively) compared to controls (197±8 ng/ml). Further, sVCAM-1 levels of patients with Crohn's disease (664±43 ng/ml) and ulcerative colitis (963±162 ng/ml) were increased ( P=0.0222 and P=0.0121, respectively) compared to controls (510±31 ng/ml). With few exceptions, serum levels of soluble adhesion molecules were not significantly correlated to disease activity indices or disease localization. Elevated circulating selectin and immunoglobulin supergene type adhesion molecules may compete with membrane-bound forms for their cognate ligands and thereby limit the rolling and stable adhesion of leukocytes. Key words P-selectin E-selectin VCAM-1 ICAM-1 Crohn's disease ulcerative colitis
These two authors contributed equally to this work. The data in this manuscript were presented, in part, at the 94th Annual Meeting of the American Gastroenterological Association, Boston, USA, May 15–21, 1993, and at the joined Annual Meeting of the Austrian and of the German Society of Immunology, Vienna, Austria, Sept. 27–30, 1995.
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