Folia Microbiologica

, 52:479

Apoptosis and aging in mitochondrial morphology mutants ofS. cerevisiae

Article

DOI: 10.1007/BF02932107

Cite this article as:
Palermo, V., Falcone, C. & Mazzoni, C. Folia Microbiol (2007) 52: 479. doi:10.1007/BF02932107

Abstract

Cell viability during chronological aging and after apoptotic stimuli in some yeast mutants with altered mitochondrial morphology was followed; a function for the corresponding genes in the apoptotic process was assessed.MDM30 andDNM1, the genes encoding an F-box protein and the dynamin-related GTPase, respectively, are involved in triggering aging and apoptosis. In contrast,YME1, encoding a subunit of the mitochondrial inner membrane i-AAA proteinase complex, has a protective role in these processes.FIS1, the mitochondrial fission gene, might play a protective role after an apoptotic insult while it seems to promote cell death in aging cells.

Abbreviations

GFP

green fluorescent protein(s)

PNPase

polyribonucleotide nucleotidyltransferase (EC 2.7.7.8)

MT

mitochondrial

Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2007

Authors and Affiliations

  1. 1.Department of Cell and Developmental Biology, Pasteur Institute-Cenci Bolognetti FoundationUniversity of Rome “La Sapienza”RomeItaly