Folia Microbiologica

, 52:479

Apoptosis and aging in mitochondrial morphology mutants ofS. cerevisiae

Authors

  • V. Palermo
    • Department of Cell and Developmental Biology, Pasteur Institute-Cenci Bolognetti FoundationUniversity of Rome “La Sapienza”
  • C. Falcone
    • Department of Cell and Developmental Biology, Pasteur Institute-Cenci Bolognetti FoundationUniversity of Rome “La Sapienza”
    • Department of Cell and Developmental Biology, Pasteur Institute-Cenci Bolognetti FoundationUniversity of Rome “La Sapienza”
Article

DOI: 10.1007/BF02932107

Cite this article as:
Palermo, V., Falcone, C. & Mazzoni, C. Folia Microbiol (2007) 52: 479. doi:10.1007/BF02932107
  • 170 Views

Abstract

Cell viability during chronological aging and after apoptotic stimuli in some yeast mutants with altered mitochondrial morphology was followed; a function for the corresponding genes in the apoptotic process was assessed.MDM30 andDNM1, the genes encoding an F-box protein and the dynamin-related GTPase, respectively, are involved in triggering aging and apoptosis. In contrast,YME1, encoding a subunit of the mitochondrial inner membrane i-AAA proteinase complex, has a protective role in these processes.FIS1, the mitochondrial fission gene, might play a protective role after an apoptotic insult while it seems to promote cell death in aging cells.

Abbreviations

GFP

green fluorescent protein(s)

PNPase

polyribonucleotide nucleotidyltransferase (EC 2.7.7.8)

MT

mitochondrial

Download to read the full article text

Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2007