Biotechnology and Bioprocess Engineering

, Volume 6, Issue 4, pp 213–230

Microencapsulation methods for delivery of protein drugs


DOI: 10.1007/BF02931982

Cite this article as:
Yeo, Y., Baek, N. & Park, K. Biotechnol. Bioprocess Eng. (2001) 6: 213. doi:10.1007/BF02931982


Recent advances in recombinant DNA technology have resulted in development of many new protein drugs. Due to the unique properties of protein drugs, they have to be delivered by parenteral injection. Although delivery of protein drugs by other routes, such as pulmonary and nasal routes, has shown some promises, to date most protein drugs are administered by parenteral routs. For long-term delivery of protein drugs by parenteral administration, they have been developed, and the currently used microencapsulation methods are reviewed here. The microencapsulation methods have been divided based on the method used. They are: solvent evaporation/extraction; phase separation (coacervation); spray drying; ionotropic gelation/polyelectrolyte complexation; interfacial polymerization; and supercritical fluid precipitation. Each method is described for its applications, advantages, and limitations.


protein peptide drug delivery microparticle microencapsulation 

Copyright information

© The Korean Society for Biotechnology and Bioengineering 2001

Authors and Affiliations

  1. 1.Departments of Pharmaceutics and Biomedical EngineeringPurdue UniversityWest LafayetteUSA

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