Folia Microbiologica

, 50:467

Antimicrobial activity of 1,2-bis-[2-(5-R)-1H-benzimidazolyl]-1,2-ethanediols, 1,4-bis-[2-(5-R)-1H-benzimidazolyl]-1,2,3,4-butanetetraols and their FeIII, CuII, and AgI complexes


  • A. Tavman
    • Department of Chemistry, Faculty of EngineeringIstanbul University
  • S. Birteksöz
    • Department of Pharmaceutical Microbiology, Faculty of PharmacyIstanbul University
  • G. Ötük
    • Department of Pharmaceutical Microbiology, Faculty of PharmacyIstanbul University

DOI: 10.1007/BF02931431

Cite this article as:
Tavman, A., Birteksöz, S. & Ötük, G. Folia Microbiol (2005) 50: 467. doi:10.1007/BF02931431


1,2-Bis-[2-(5-H/Me/Cl/NO2)-1H-benzimidazolyl]-1,2-ethanediols (L1L4), 1,4-Bis-[2-(5-H/Me/Cl)-1H-benzimidazolyl]-1,2,3,4-butanetetraols (L5L7) and their complexes with FeCl3, CuCl2, and AgNO3 were synthesized; antibacterial activity of the compounds was determined towardStaphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, Proteus mirabilis, and antifungal activity againstCandida albicans. The AgI complexes have considerable activity toward the microorganisms. Some AgI complexes show higher activity towardS. epidermidis than AgNO3 and cefuroxime. Cu(L3)Cl2 and Fe(L3)Cl3 show an antifungal effect onC. albicans butL3 itself has no activity.

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© Institute of Microbiology, Academy of Sciences of the Czech Republic 2005