Session 4 Bioengineering Research

Applied Biochemistry and Biotechnology

, Volume 34, Issue 1, pp 543-556

First online:

Mathematical modeling of cellulose conversion to ethanol by the simultaneous saccharification and fermentation process

  • George P. PhilippidisAffiliated withBiotechnology Research Branch, Fuels and Chemicals Research and Engineering Division, National Renewable Energy Laboratory
  • , Diane D. SpindlerAffiliated withBiotechnology Research Branch, Fuels and Chemicals Research and Engineering Division, National Renewable Energy Laboratory
  • , Charles E. WymanAffiliated withBiotechnology Research Branch, Fuels and Chemicals Research and Engineering Division, National Renewable Energy Laboratory

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Ethanol, a promising alternative fuel, can be produced by the simultaneous saccharification and fermentation (SSF) of lignocellulosic biomass, which combines the enzymatic hydrolysis of cellulose to glucose and the fermentation of glucose to ethanol by yeast in a single step.

A mathematical model that depicts the kinetics of SSF has been developed based on considerations of the quality of the substrate and enzyme, and the substrate-enzyme-microorganism interactions. Critical experimentation has been performed in conjunction with multiresponse nonlinear regression analysis to determine key model parameters regarding cell growth and ethanol production. The model will be used for rational SSF optimization and scale-up.

Index Entries

Cellulose hydrolysis SSF modeling biomass conversion ethanol production