Immunologic Research

, Volume 11, Issue 3, pp 260–272

Expression, regulation and function of human FcεRII (CD23) antigen

  • M. Sarfati
  • S. Fournier
  • C. Y. Wu
  • G. Delespesse
Expression, Regulation and Function of Human CD23

DOI: 10.1007/BF02919132

Cite this article as:
Sarfati, M., Fournier, S., Wu, C.Y. et al. Immunol Res (1992) 11: 260. doi:10.1007/BF02919132

Abstract

CD23, also known as the low affinity receptor for IgE (FcεRII), belongs to a novel superfamily of type-II integral membrane proteins. FcεRII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by several cytokines (i.e., interleukin-4, interferons) in a tissue-specific manner. In some pathological conditions such as B-chronic lymphocytic leukemia, the CD23 gene is abnormally regulated resulting in CD23 overexpression. CD23 is not only an IgE receptor but also a membrane-bound precursor of soluble molecules that still bind IgE (sCD23 or IgE-binding factors). The functions of membrane CD23 are IgE-dependent and vary according to the cell types on which it is expressed. In contrast, sCD23, in addition to being an IgE regulatory molecule, displays multiple cytokine activities that are IgE-independent.

Key Words

CD23FcεRIIIgE-binding factorsChronic lymphocytic leukemia

Copyright information

© Humana Press Inc. 1992

Authors and Affiliations

  • M. Sarfati
    • 1
  • S. Fournier
    • 1
  • C. Y. Wu
    • 1
  • G. Delespesse
    • 1
  1. 1.Notre-Dame Hospital, Research CentreUniversity of MontrealMontrealCanada