The Year in Complement

Immunologic Research

, Volume 12, Issue 3, pp 244-257

First online:

Membrane signaling by complement C5b-9, the membrane attack complex

  • Anne Nicholson-WellerAffiliated withDepartment of Medicine, Brigham and Women's HospitalDepartment of Cellular and Molecular Physiology, Harvard Medical SchoolCharles A. Dana Research Institute, Harvard Thorndike Laboratories, Beth Israel Hospital, Harvard Medical SchoolDepartment of Medicine, Beth Israel Hospital, Harvard Medical SchoolDivision of Infections Disease, Beth Israel Hospital
  • , Jose A. HalperinAffiliated withDepartment of Medicine, Brigham and Women's HospitalDepartment of Cellular and Molecular Physiology, Harvard Medical SchoolCharles A. Dana Research Institute, Harvard Thorndike Laboratories, Beth Israel Hospital, Harvard Medical SchoolDepartment of Medicine, Beth Israel Hospital, Harvard Medical School

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Abstract

The terminal complement complexes C5b-7, C5b-8 and C5b-9 are able to generate nonlethal cell signals. One universal consequence of a cell being targeted by C5b-8 or C5b-9 is an influx of Ca2+. In addition, other second messengers, including cAMP, inositol phosphate intermediates and arachidonate metabolites, are generated by the terminal complement complexes in specific cell types. In vivo, terminal complement complexes have been found in a wide variety of inflammatory processes in humans and in experimental animal models. Some of these models of inflammation putatively induced by terminal complement complexes have been tested in complement-deficient animals, and indeed no inflammation results, which supports the critical role of the terminal complement complexes in the pathogenesis of the lesion.

Key Words

Ca2+ influx Arachidonic acid Vitronectin Inflammation Mitogenesis