Proxidant and antioxidant status in patients of type II Diabetes Mellitus with IHD
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Patients with type II Diabetes Mellitus (NIDDM) are more prone to Ischaemic Heart Disease (IHD). Although, oxygen free radicals are known to contribute to the development of IHD, conflicting reports are available regarding the antioxidant status in patients of NIDDM complicated with IHD. This study was undertaken to investigate the oxidative status in patients of NIDDM and to assess their correlation with plasma glucose, glycosylated haemoglobin and duration of diabetes. The levels of malondialdehyde were significantly increased where as levels of superoxide dismutase, Glutathione peroxidase and vitamin C were significantly decreased in diabetics without complications and non-diabetics with IHD when compared with the controls. The levels of malondialdehyde and Glutathione peroxidase were significantly increased where as levels of superoxide dismutase and vitamin C were significantly decreased in diabetics with IHD when compared with diabetics without complications and non-diabetics with IHD. The implications of the results are discussed.
- Cardiovascular Health Research Initiative (2003): Global burden of cardiovascular disease. South Asian Journal of Preventive Cardiology. Vol 7 no 2, 69–71.
- Kannel, W.B. and McGee, D.L. (1979) Diabetes and cardiovascular disease: The Framingham study. JAMA. 241: 2035–38. CrossRef
- Stamler, J., Vaccaro O., Neaton, J.D. and Wentworth, D. (1993) The multiple risk factor Intervention Trial Research Group: Diabetes other risk factors and 12 year cardiovascular mortality for men screened in the multiple risk factor Intervention Trial. Diabetes Care 16, 434–44. CrossRef
- Wagenknecht, L.E., Bowden, D.W., Carr, J.J., Langefeld, C.D., Freedman, B.J. and Rich, S.S. (2001) Familial aggregation of coronary artery calcium in families with type 2 diabetes. Diabetes 50, 861–66. CrossRef
- Jakus, V. (2000) The role of free radicals, oxidative stress and antioxidant systems in diabetic vascular disease Bratisl. Lek. Listy. 101(10), 541–51.
- Artemeva, G.B., Rahita, D.R. and Uzbekova, D.G. (1990) The effect of parmidine on the lipid peroxidation processes in coronary atherrosclerosis. Farmakol. Toksikol. 53, 56–8.
- Merzouk, S., Hichami, A., Madani, S. and Merzouk, H. (2003) Antioxidant status and levels of different vitamins determined by HPLC in diabetic subjects with multiple complications. Gen. Physiol. Biophys. March 22(1), 15–27.
- Kesavulu, M.M., Rao, B.K. and Giri, R. (2001) Lipid peroxidation and antioxidant enzyme status in type 2 diabetes with coronary artery disease. Diabetes Res. Clin. Pract. 53(1), 33–9. CrossRef
- Jang, Y., Leo, J.H., Cho, E.Y. and Chung, N.S. (2001) Differences in body fat distribution and antioxidant status in korean men with cardiovascular with and without diabetes. Am. J. Clin. Nutr. 73(1), 68–74.
- Friedewalds, W.T., Levy, R.I. and Fredrickson, D.S. (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge. Clin. Chem. 18, 499–502.
- Arthur, J.R. and Boyne, R. (1985) Superoxide dismutase and glutathione activities in neutrophils from selenium defecient and copper deficient cattle. Life Sciences 3, 1569–1575. CrossRef
- Kyaw, A. (1978) A simple colorimetric method for ascorbic acid determination in blood. Clinica. Chimica. Acta. 86, 153–157. CrossRef
- Paglia, D.E. and Valentine, W.N. (1967) Studies in the qualitative and quantitative characterization of erythrocytic glutathione peroxidase. J. Lab. Clin. Med. 70, 158–169.
- Matkovics, B., Kotorman, M. and Varga, I.S. (1997-98) Pro, antioxidant studies in the blood of type 2 diabetic patients. Acta. Physiol. Hung. 85(2), 107–12.
- Sundaram, R.K., Bhaskar, A. and Vijayalingam, S. (1996) Antioxidant status and lipid peroxidation in type II diabetes mellitus with and without complications. Clin. Science 90, 255–60.
- Esposito, K. and Giugliano, D. (2002) Hyperglycemia and vascular damage: Role of oxidative stress. Recent Prog. Med. 93(3), 172–4.
- Giugliano, D., Ceriello, A. and Paolisso, G. (1995) Diabetes Mellitus, Hypertension, and Cardiovascular Disease: Which role for oxidative stress? Metabolism 44 (3), 363–368. CrossRef
- Pordrez, E.A., Abu Soud, H.M. and Hazen, S.L. (2000) Myeloperoxidase generated oxidants and atheosclerosis. Free Radic. Biol. Med. 28, 1717–1725. CrossRef
- Uchida, R. (2000) Role of reactive aldehyde in cardiovascular disease. Free Radic. Med. Biol. 28, 1685–1696. CrossRef
- Ehara, S., Ueda, M. and Naruko, T. (2002) Pathophysiological role of oxidised LDL in plaque instability in coronary artery disease. J. Diabetes and its complications 16, 60–64. CrossRef
- Govindraju, V., Neelam and Manjunath, G.N. (2003) Hyperhomocysteinemia: an emerging risk factor for cardiovascular disease. Ind. J. Clin. Biochem. 18(1), 8–14. CrossRef
- Narsuzcwicz, M., Mirkiewicz, E. and Olszewski, A.J. (2003) Thiolation of IDL by homocyteine thiolactone causes increased aggregation and altered interaction with cultured macrophages. Nutr. Metab. Cardiovasc. Dis. 4, 70–77.
- Heinecka, T.W. (1988) Superoxide mediated oxidation of IDL by thiols. In: Cerutti PA, Fridovich I, McCord TM eds Oxy radicals in molecular biology and pathology, New York Alan R. Liss. 443–57.
- Uzel, N., Sivas, A. and Uysal, M. (1987) Erythrocyte lipid peroxidation and glutathione peroxidase activities in patients with diabetes mellitus. Horm. Metab. Res. 19, 89–90. CrossRef
- Sinclair, A.J., Girling, A.J. and Gray, L. (1991) Disturbed handling of ascorbic acid in diabetic patients with and without microangiopathy during high dose ascorbate supplementation. Diabetologia 34: 171–175. CrossRef
- Blaustein, A., Deneke, S.M. and Stolz, R.I. (1989) Myocardial glutathione depletion impairs recovery after short period of ischemia. Circulation 80, 1449–57.
- Mezzetti, A., Dillio, C. and Calafiore, A.M. (1990) Glutathione peroxidase, glutathione reductase and glutathione transferase activities in human artery, vein and heart. J. Mol. Cell Cardiol. 22, 935–8. CrossRef
- Proxidant and antioxidant status in patients of type II Diabetes Mellitus with IHD
Indian Journal of Clinical Biochemistry
Volume 21, Issue 2 , pp 118-122
- Cover Date
- Print ISSN
- Online ISSN
- Springer India
- Additional Links
- Non insulin Dependent Diabetes Mellitus
- Ischaemic Heart Disease
- oxidative status