False positive reaction for carcinoembryonic antigen in paget cells
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- Sumitomo, S., Tatemoto, Y., Fukui, S. et al. Virchows Archiv B Cell Pathol (1985) 49: 395. doi:10.1007/BF02912116
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Paget cells from cases of mammary and extramammary Paget’s disease were examined for carcinoembryonic antigen (CEA) and CEA-related antigens by the immunoperoxidase method. Paget cells showed a conspicuous positive reaction with antiserum to CEA, but were negative when nonspecific cross-reacting-antigen (NCA)-absorbed antiserum to CEA, or a monoclonal antibody to CEA was used as the detecting agents. Paget cells may contain large amounts of NCA antigen or CEA-related substances.