, Volume 17, Issue 2, pp 164-176

Literature highlights—29

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Summary

This review looks at developments in the chemistry of cisplatin,cis-[Pt(NH3)2Cl2], and its relatives, such ascis-[Pt(NH3)2(OH2)2]2+. Particular attention is paid to substitution reactions involving thecis-PtII(NH3)2 centre. This moiety will form coordination compounds with phosphates, thiolates, thioethers, amines and carboxylates, interesting examples being provided by aminoacids including those containing thiol groups. Though usually inert, thecis-PtII(NH3)2 unit can be destroyed by cyanide ions and by thiourea. The kinetics of reactions with mononucleosides and mononucleotides provide models for the attack of cisplatin on DNA. In nucleotide chains thecis-PtII(NH3)2 moiety has a particular affinity for GG units forming Pt(GG) chelates, although species such as Pt(GTG) can be formed. There is evidence that the attack ofcis-[Pt(NH3)2Cl2] andcis-[Pt(NH3)2(OH2)2]2+ on DNA is a four step process.