Epidemiology of inflammatory bowel diseases in childhood
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Inflammatory Bowel Disease (IBD) is common in most industrialised countries and childhood IBD accounts for nearly 30% of total cases. Various studies, mostly from Europe and USA have reported epidemiological characteristics of childhood IBD. The incidence figures vary greatly from region to region and within a region over time. Almost all reported studies have documented an increase in the incidence, mainly of Crohn’s disease over the last few decades. The reasons for the increase are not clear but epidemiological observations have led to many postulates. Incidence in developing countries is perceived to be low, but limited data suggest that it may not be as uncommon as previously thought. IBD can occur at any age but is rare in infancy. Among childhood IBD, early onset IBD appears to be different epidemiologically and is characterised by predominance of colonic involvement and high positive family history. It has become apparent that only about 25% of childhood Crohns disease presents with classical triad of abdominal pain, diarrhoea and weight loss. Pediatricians should be aware of atypical manifestations and should maintain high index of suspicion.
Though epidemiological studies of childhood IBD done so far have contributed towards understanding of IBD, they have differed in study design, population, time period, age group and case definitions. Unfortunately there are no uniform, clear diagnostic criteria which are evidence based. To address this problem, recently the IBD working group of European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) has published “The Porto Criteria” which details a consensus based diagnostic criteria for the diagnosis of childhood IBD. This should bring uniformity in ascertainment of newly diagnosed IBD cases. An European multicentre prospective database has also been established to facilitate future epidemiological studies.
- Sawczenko A, Sandhu B. Presenting features of inflammatory bowel disease in Great Britain and Ireland.Arch Dis Child 2003; 88: 995–1000. CrossRef
- Heyman MB, Kirschner BS, Gold BDet al. Children with early onset inflammatory bowel disease (IBD): Analysis of a pediatric IBD consortium registry.J Pediatr 2005; 146: 35–40. CrossRef
- Griffiths AM. Specificities of inflammatory bowel disease in childhood.Best Pract Res Clin Gastroenterol 2004; 18(3): 509–523. CrossRef
- Russel MGV. Epidemiology of Inflammatory bowel disease: and update.Scand J Gastroenterol 1996; 31: 417–427. CrossRef
- Sawczenko A, Sandhu BK, Logan RFAet al. Prospective survey of childhood inflammatory bowel disease in the British Isles.Lancet 2001; 357: 1093–1094. CrossRef
- Lindberg E, Lindquist B, Holmquist Let al. Inflammatory bowel disease in children and adolescents in Sweden 1984–1995.J Pediatr Gastroenterol Nutr 2000; 30: 259–264. CrossRef
- Hildbrand H, Finkel Y, Grahnquist Let al. Changing pattern of pediatric inflammatory bowel disease in northern Stockholm 1990–2001.Gut 2003; 52: 1432–1434. CrossRef
- van der Zaag-Loonen HJ, Casparie M, Taminiau JAJMet al. The incidence of Paediatric inflammatory bowel disease in the Netherlands 1999–2001.J Peditr Gastroenterol Nutr 2004; 38: 302–307. CrossRef
- Bjornsson S, Johannsson JH. Inflammatory bowel disease in Iceland, 1990–1994: a prospective, nationwide, epidemiological study.Eu J Gastroenterol Hepatol 2000; 12: 31–38.
- Auvin S, Molinie F, Gower-Rousseau Cet al. Incidence, clinical presentation and location at diagnosis of pediatric inflammatory bowel disease: A prospective population based study in northern France from 1988–1999.J Pediatr Gastroentrol Nutr 2005; 41: 40–55.
- Kugathasan S, Judd RH, Hoffmann RGet al. Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a state wide population based study.J Pediatr 2003; 143: 525–531. CrossRef
- Buller HA. Problems in diagnosis of Inflammatory Bowel Disease in children.Neth J Med 1997; 50(2) S 8–11. CrossRef
- Mehta S. Inflammatory bowel disease in children: Indian perspective.Indian J Pediatr 1999; 66 (1supl): S 87–88. CrossRef
- Sood A, Midha V, Sood Net al. Incidence and Prevalence of UC in Punjab, North India.Gut 2003; 52: 1587–1590. CrossRef
- Mamula P, Telega GW, Markowitz JEet al. Inflammatory bowel disease in children 5 years of age and younger.Am J Gastroenterol 2002; 97: 2005–2010. CrossRef
- Sonnenberg A, McCarty DJ, Jacobsen SJ. Geographic variation of inflammatory bowel disease with in the united states.Gastroenterology 1991; 100: 143–149.
- Shivananda A, Lennard-Jones J, Logan R—the EC-IBD study group et al. Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European collaborative study on the inflammatory bowel disease (EC-IBD).Gut 1996; 39: 690–697. CrossRef
- Armitage E L, Aldhous M C, Anderson N et al. Incidence of juvenile-onset Crohn’s disease in Scotland: Association with northern latitude and affluence.Gastroenterology 2004;127: 1051–1057. CrossRef
- Card T R, Sawczencko A, Sandhu BKet al. No seasonality in month of Birth of IBD cases: a prospective population based study of British under 20 year olds.Gut 2002; 51: 814–815. CrossRef
- Barton J R, Gillon S, Ferguson A. Incidence of inflammatory bowel disease in Scottish children between 1968 and 1983: Marginal fall in ulcerative colitis, three fold increase in Crohn’s disease.Gut 1989; 30: 618–622. CrossRef
- Cosgrove M, Al-Atia R F, Jnkins H R. The epidemiology of pediatric inflammatory bowel disease.Arch Dis Child 1996; 74: 460–461. CrossRef
- Langholz E, Munkholm P, Krasilinikoff PAet al. Inflammatory bowel disease with onset in childhood. Clinical features, morbidity and mortality in a regional cohort.Scand J Gastroenterol 1997; 32: 139–147. CrossRef
- Devadason D, Hussein H, Sprayet al. The incidence of Ulcerative Colitis has doubled since 1999.J Pediatr Gastroenterol Nutr 2005; 40 (5): 643.
- Buller H, Chin S, Kirschner Bet al. Inflammatory bowel disease in children and adolescents: Working group report of first world congress of paeidatric gastroenterology hepatology and nutrition.J Pediatr Gastroenterol Nutr 2002; 35: S 151–158. CrossRef
- Montgomery SM, Pounder RE, Wakefield AJ. Infant mortality and the incidence of inflammatory bowel disease.Lancet 1997; 349: 472–473. CrossRef
- Bonen D K, Cho J H. The genetics of inflammatory bowel disease.Gastroenterology 2003; 124(2): 521–536. CrossRef
- Probert C J S, Jayanthi V, Pinder Det al. Epidemiological study of ulcerative colitis in Indian migrants and the indigenous population of Leicestershire.Gut 1992; 33: 687–693. CrossRef
- Jayanthi V, Probert CJS, Pinder Det al. Epidemiology of Crohn’s disease in Indian migrants and the indigenous population in Leicestershire.Q J Med 1992; 82: 125–138.
- Inflammatory bowel diseases in children and adolescents: Recommendations for diagnosis—The Porto Criteria. IBD Working group of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN).J Pediatr Gastroenterol Nutr 2005; 41: 1–7.
- Epidemiology of inflammatory bowel diseases in childhood
The Indian Journal of Pediatrics
Volume 73, Issue 8 , pp 717-721
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