, Volume 16, Issue 1, pp 79-87

The influence of serotonin on crypt cell proliferation in the jejunum of rat

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The influence of injected serotonin and of serotonin depletion on crypt cell cycle time and mitotic time in rat jejunum was studied.

Small doses of serotonin (10 μg/kg) were found to shorten crypt cell cycle time whereas very large doses (300 mg/kg) prolonged both the cell cycle and mitotic time. Partial serotonin depletion following injection of 6-fluorotryptophan was also found to retard crypt cell cycle time and mitotic time.