Pathology & Oncology Research

, Volume 12, Issue 2, pp 105–107

The nested variant of urothelial carcinoma: an aggressive tumor closely simulating benign lesions

Cask Report

DOI: 10.1007/BF02893453

Cite this article as:
Dundar, E., Acikalin, M.F. & Can, C. Pathol. Oncol. Res. (2006) 12: 105. doi:10.1007/BF02893453


The “nested” variant is a rare form of urothelial carcinoma and its biologic behavior is highly aggressive. Herein two new cases of nested variant of urothelial carcinoma with immunohistochemical examination are presented. In one of the cases, the tumor extended through the bladder wall into the perivesicular soft tissue, prostatic urethra and left vesicula seminalis, and metastasized to obturator lymph nodes. In the other case, invasion of muscular layer was observed and three recurrences were developed during a followup period of 23 months. Both tumors of our study demonstrated high p53 and Ki-67 indices, supporting the aggressive nature of such tumors.(Pathology Oncology Research Vol 12, No 2, 105–107)

Key words

urothelial carcinoma nested variant 

Copyright information

© Arányi Lajos Foundation 2006

Authors and Affiliations

  • Emine Dundar
    • 1
  • Mustafa Fuat Acikalin
    • 1
  • Cavit Can
    • 2
  1. 1.Department of PathologyOsmangazi Üniversitesi Tip Fakültesi Patoloji Anabilim DaliEskisehirTurkey
  2. 2.Department of UrologyOsmangazi University Medical FacultyEskisehirTurkey

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